Energetic constraints on filament mediated cell polarization [PDF]
, 2021 Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on the membrane and create a high density spot of membrane-bound proteins.
arxiv +1 more source
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]
, 2019 Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister +77 more
core +1 more source
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
core +2 more sources
A new framework for identifying combinatorial regulation of transcription factors: a case study of the yeast cell cycle [PDF]
Journal of Biomedical Informatics Volume 40, Issue 6, December
2007, Pages 707-725. Intelligent Data Analysis in Biomedicine, 2010 By integrating heterogeneous functional genomic datasets, we have developed a new framework for detecting combinatorial control of gene expression, which includes estimating transcription factor activities using a singular value decomposition method and reducing high-dimensional input gene space by considering genomic properties of gene clusters.
arxiv +1 more source
Acanthamoeba induces cell-cycle arrest in host cells [PDF]
, 2004 Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alizadeh +41 more
core +1 more source
Drug targets for cell cycle dysregulators in leukemogenesis: in silico docking studies. [PDF]
PLoS ONE, 2014 Alterations in cell cycle regulating proteins are a key characteristic in neoplastic proliferation of lymphoblast cells in patients with Acute Lymphoblastic Leukemia (ALL).
Archana Jayaraman, Kaiser Jamil
doaj +1 more source
Modelling how plant cell-cycle progression leads to cell size regulation.
PLoS Computational Biology, 2023 Populations of cells typically maintain a consistent size, despite cell division rarely being precisely symmetrical. Therefore, cells must possess a mechanism of "size control", whereby the cell volume at birth affects cell-cycle progression.
Daniel Williamson +4 more
doaj +1 more source
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
Mathematics, 2022 Biological processes are governed by the expression of proteins, and for some proteins, their level of expression can fluctuate periodically over time (i.e., they oscillate).
Andrew Rowntree +2 more
doaj +1 more source
Alterations in cell cycle profile and cell cycle protein expression in neuroblastoma cells stably transfected with tau protein [PDF]
BMC Neuroscience, 2007 Alzheimer's disease is characterized by extracellular deposition of beta amyloid peptide and intracellular deposition of hyperphosphorylated tau protein in isocortical brain areas. Recently, we and others have shown that vulnerable neurons or tau aggregate-bearing neurons aberrantly express cell cycle proteins namely cdk inhibitors. In order to analyse
Max Holzer +5 more
openaire +3 more sources