Results 51 to 60 of about 1,825,024 (378)

Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]

, 2011
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara, Boudolf, Véronique, De Jaeger, Geert, De Veylder, Lieven, De Wit, Kevin, Heyman, Jefri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Van Den Daele, Hilde, Verkest, Aurine   +9 more
core   +2 more sources

Deterministic and stochastic descriptions of gene expression dynamics [PDF]

J. Stat. Phys. 148, 607-626 (2012), 2012
A key goal of systems biology is the predictive mathematical description of gene regulatory circuits. Different approaches are used such as deterministic and stochastic models, models that describe cell growth and division explicitly or implicitly etc.
arxiv   +1 more source

Cell cycle and protein complex dynamics in discovering signaling pathways [PDF]

Journal of Bioinformatics and Computational Biology 2019, 2020
Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount of biological data available and the recent discoveries showing that many diseases are related to the disruption of cellular signal ...
arxiv   +1 more source

Mitotic waves in an import-diffusion model with multiple nuclei in a shared cytoplasm [PDF]

arXiv, 2021
Nuclei import and export proteins, including cell cycle regulators. These import-export processes are modulated periodically by the cell cycle, for example due to the periodic assembly and breakdown of the nuclear envelope. As such, replicated DNA can be segregated between the two daughter cells and the proteins that were localized in the nucleus are ...
arxiv  

Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle [PDF]

, 2009
gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
A Rickinson, AD Hislop, AD Hislop, Alan B. Rickinson, Andrew D. Hislop, Andrew I. Bell, B Park, Bill Sugden, BJ Biegalke, BN Lilley, C Bogedain, Claire Shannon-Lowe, Daniëlle Horst, DJ Tenney, E Scotet, Elisabeth Kremmer, Emmanuel J. H. J. Wiertz, G Lautscham, HJ Delecluse, J Yuan, J Zuo, J Zuo, Jaap M. Middeldorp, JC Stinchcombe, JW Yewdell, JX Zhang, K Takada, L Young, LS Young, M Buisson, M Kishishita, M Rowe, Maaike E. Ressing, Martin Rowe, MC Gold, ME Ressing, MT Vossen, MW Munks, Nathan P. Croft, NM Steven, P Rivailler, PG Stevenson, R Feederle, S Keating, TA Groothuis, TR Jones, TR Jones, V Bohm, VA Pudney, WM van Grunsven, X Saulquin, Y Zeng   +51 more
core   +6 more sources

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Bertrand, Philippe, Bretteville, Alexis, Buée, Luc, Bégard, Séverine, Delacourte, André, Hamdane, Malika, Sambo, Anne-Véronique, Schindowski, Katharina   +7 more
core   +1 more source

Dynamical Analysis of Yeast Cell Cycle Using a Stochastic Markov Model

مجله انفورماتیک سلامت و زیست پزشکی, 2021
Introduction: The cell cycle network is responsible of control, growth and proliferation of cells. The relationship between the cell cycle network and cancer emergence, and the complex reciprocal interactions between genes/proteins calls for ...
Sajad Shafiekhani, Azam Sadat Fatemi, Gelayol Nazari Golpayegani, Seyed Yashar Banihashem, Amir Homayoun Jafari   +4 more
doaj  

Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells

Journal of the Formosan Medical Association, 2007
The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown. Methods: These mechanisms were explored using ETB-overexpressing opossum kidney (OKP) cells as a model system. Results: ET-1
Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh   +3 more
doaj   +1 more source

Exact solution of stochastic gene expression models with bursting, cell cycle and replication dynamics [PDF]

Phys. Rev. E 101, 032403 (2020), 2019
The bulk of stochastic gene expression models in the literature do not have an explicit description of the age of a cell within a generation and hence they cannot capture events such as cell division and DNA replication. Instead, many models incorporate cell cycle implicitly by assuming that dilution due to cell division can be described by an ...
arxiv   +1 more source

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan, Khalil, Hilal S., Lane, David P., Tummala, Hemanth, Zhelev, Nikolai   +4 more
core   +3 more sources