Results 61 to 70 of about 1,825,024 (378)

Expressão de marcadores de proliferação celular e apoptose em carcinoma basocelular Markers expression of cell proliferation and apoptosis in basal cell carcinoma

Anais Brasileiros de Dermatologia, 2009
FUNDAMENTOS: O carcinoma basocelular é o câncer mais comum em humanos. Estudos que utilizam recursos da biologia molecular e genética, associados à histomorfologia, permitem a identificação de fatores de risco no desenvolvimento de lesões mais ...
Marília de Pádua Dornelas Corrêa, Ana Paula Ferreira, Ângela Maria Gollner, Michele Fernandes Rodrigues, Magno Cunha de Souza Guerra   +4 more
doaj   +1 more source

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. [PDF]

, 2011
BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks
A Chicheportiche, A Jazayeri, A Moumen, A Sancar, Abdeladim Moumen, C Zhou, CL Brooks, E Drakos, EP Rogakou, H Zhao, HH Li, Jane M Valentine, JG Jackson, JS Myers, K Oda, KH Vousden, L Chen, LT Vassilev, M Hollstein, MW Jackson, NH Chehab, O Fernandez-Capetillo, P Secchiero, Q Cheng, R Maya, R Verma, RL Warters, S Herold, Sonia Kumar, T Thompson, T Unger, T Unger, TR Shirangi, V Tergaonkar, X Cai   +34 more
core   +3 more sources

Oscillatory dynamics of cell cycle proteins in single yeast cells analyzed by imaging cytometry. [PDF]

PLoS ONE, 2011
Progression through the cell division cycle is orchestrated by a complex network of interacting genes and proteins. Some of these proteins are known to fluctuate periodically during the cell cycle, but a systematic study of the fluctuations of a broad ...
David A Ball, Julie Marchand, Magaly Poulet, William T Baumann, Katherine C Chen, John J Tyson, Jean Peccoud   +6 more
doaj   +1 more source

Novel Therapies for Tongue Squamous Cell Carcinoma Patients with High-Grade Tumors

Life, 2021
Background: Tongue squamous cell carcinoma (TSCC) patients with high-grade tumors usually suffer from high occurrence and poor prognosis. The current study aimed at finding the biomarkers related to tumor grades and proposing potential therapies by these
Yinghua Li, Hao Lin, Lu Chen, Zihao Chen, Weizhong Li   +4 more
doaj   +1 more source

Pocket proteins and cell cycle control [PDF]

Oncogene, 2005
The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes.
openaire   +2 more sources

Stable stochastic dynamics in yeast cell cycle [PDF]

, 2007
Chemical reactions in cell are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of cell is kept stable against those noisy perturbations. In this paper a stochastic model of cell cycle of budding yeast is constructed to analyze the effects of noise on the cell cycle oscillation.
arxiv   +1 more source

A hybrid mammalian cell cycle model [PDF]

EPTCS 125, 2013, pp. 68-83, 2013
Hybrid modeling provides an effective solution to cope with multiple time scales dynamics in systems biology. Among the applications of this method, one of the most important is the cell cycle regulation. The machinery of the cell cycle, leading to cell division and proliferation, combines slow growth, spatio-temporal re-organisation of the cell, and ...
arxiv   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Proteins Made in the Mammalian Cell Cycle

Journal of Biological Chemistry, 1971
DNA-binding proteins made by Chinese hamster ovary (CHO) cells at specific times in their cell cycle were chromatographed on DNA-cellulose and analyzed with sodium dodecyl sulfate polyacrylamide electrophoresis. Some small proteins (less than 25,000 mol wt) were made in S (the period of DNA synthesis), but not during G1 (the period following mitosis ...
Thomas O. Fox, Arthur B. Pardee
openaire   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source