Results 81 to 90 of about 9,442,423 (244)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Conserved Cell Growth Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotes [PDF]

, 2012
The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC).
Airoldi, Edoardo|, Airoldi, E.M., Airoldi, EM, Airoldi, Edoardo M, Botstein, D., van Oudenaarden, Alexander, Airoldi, Edoardo, Van Oudenaarden, A, Botstein, David, Slavov, Nikolai G, Botstein, D, Slavov, N., Airoldi, Edoardo M., Slavov, N, van Oudenaarden, A., Slavov, Nikolai   +15 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative and functional analysis of the archaeal cell cycle

, 2010
The temporal and spatial organization of the chromosome replication, genome segregation and cell division processes is less well understood in species belonging to the Archaea, than in those from the Bacteria and eukarya domains.
Bernander, Rolf,, Lundgren, Magnus,, Thijs J. G. Ettema, Magnus Lundgren, Rolf Bernander, Ettema, Thijs J. G.,, Lundgren, Magnus, Ettema, Thijs J.G., Bernander, Rolf   +8 more
core   +1 more source

Identification of transcriptional and metabolic programs related to mammalian cell size [PDF]

, 2014
Background Regulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and ...
Mlettinen, Teemu P., Pessa, Heli K. J., Bjoerklund, Mikael, Diril, M. Kasim, Pessa, Heli K.J., Sauer, Uwe; id_orcid, Fuhrer, Tobias, Kaldis, Philipp, Sauer, Uwe, Bjorklund, Mikael, DİRİL, MUHAMMED KASIM, Caldez, Matias J., Miettinen, Teemu P.   +12 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Caloric restriction causes symmetric cell division and delays aging in Escherichia coli [PDF]

, 2008
Aging is one of the most intriguing processes of biology and despite decades of research, many aspects of aging are poorly understood. Aging is known to occur in bacteria and yeast that divide with morphological asymmetry.
Milind G. Watve, Snehal Bari, Uttara Lele, Samit Watve, Prajakta Belsare, Sarika Karande   +5 more
core  

Endothelial cell division in angiogenic sprouts of differing cellular architecture [PDF]

, 2015
The vasculature of the zebrafish trunk is composed of tubes with different cellular architectures. Unicellular tubes form their lumen through membrane invagination and transcellular cell hollowing, whereas multicellular vessels become lumenized through a
Markus Affolter, Lenard, Anna, Sauteur, Loïc, Affolter, Markus, Denes, Alexandru Stefan, Belting, Heinz-Georg, Vahap Aydogan, Loic Sauteur, Aydogan, Vahap, Anna Lenard, Alexandru Stefan Denes, Heinz-Georg Belting   +11 more
core   +1 more source

Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor

Frontiers in Molecular Biosciences
Wilms tumor (WT) is a pediatric kidney cancer associated with poor outcomes in patients with unfavorable histological features such as anaplasia. Small non-coding RNAs, such as miRNAs, are known to be involved in WT pathogenesis. However, research on the
Fatma S. Mohamed, Fatma S. Mohamed, Deena Jalal, Youssef M. Fadel, Samir F. El-Mashtoly, Wael Z. Khaled, Wael Z. Khaled, Ahmed A. Sayed, Ahmed A. Sayed, Mohamed A. Ghazy, Mohamed A. Ghazy   +10 more
doaj   +1 more source