Results 141 to 150 of about 11,204,396 (257)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

The BfmRS stress response protects Acinetobacter baumannii against defects in outer membrane lipoprotein biogenesis

Journal of Bacteriology
The outer membrane (OM) of Gram-negative bacteria is the outermost layer of the cell and serves as permeability barrier against environmental toxins, including antibiotics.
Julianna Marotta, Alan Zhao, Philip N. Rather, Marcin Grabowicz   +3 more
doaj   +1 more source

The bacterial cell envelope.

Cold Spring Harbor Perspectives in Biology, 2010
T. Silhavy, D. Kahne, S. Walker
semanticscholar   +1 more source

Radiation‐Resistant Aluminum Alloy for Space Missions in the Extreme Environment of the Solar System

Advanced Materials, EarlyView.
A novel ultrafine‐grained aluminum crossover alloy exhibits unprecedented radiation resistance and mechanical stability under extreme irradiation doses up to 100 dpa. The exceptional resilience arises from thermodynamically stable T‐phase precipitates, enabling lightweight structural materials for next‐generation spacecraft and extraterrestrial ...
Patrick D. Willenshofer, Matheus A. Tunes, Hi T. Vo, Lukas Stemper, Markus Alfreider, Oliver Renk, Graeme Greaves, Daniel Kiener, Peter J. Uggowitzer, Stefan Pogatscher   +9 more
wiley   +1 more source

Peptidoglycan LD-Transpeptidases

Antibiotics
LD-Transpeptidases (LDTs) are a widely conserved class of peptidoglycan (PG) crosslinking enzymes in bacteria. They are sometimes overlooked as they often act secondary to penicillin binding proteins (PBPs) under standard conditions.
Samuel Gastrell, Waldemar Vollmer
doaj   +1 more source

Breaking the 2‐nm Barrier in Hard Disk Drives Using Monolayer Amorphous Carbon Overcoats

Advanced Materials, EarlyView.
The rapid growth of AI has increased demand for large‐scale data storage, making HDDs indispensable in data centers. Increasing areal storage density is crucial, but limited by the traditional carbon overcoats (COC). Monolayer amorphous carbon (MAC) offers a superior alternative.
Hongji Zhang, Artem K. Grebenko, Dmitrii Litvinov, Wenwen Zheng, Konstantin V. Iakoubovskii, Sergey Y. Grebenchuk, Anna Makarova, Alexander Fedorov, Andrei Starkov, Carlo M. Orofeo, Denis V. Vyalikh, Mario Lanza, Maciej Koperski, Kostya S. Novoselov, Chee‐Tat Toh, Barbaros Ӧzyilmaz   +15 more
wiley   +1 more source

Disruptions in outer membrane-peptidoglycan interactions enhance bile salt resistance in O-antigen-producing E. coli

mBio
Bile salts (BS) are antimicrobials that disrupt bacterial cell membranes and induce oxidative stress. The gut bacterium Escherichia coli is naturally resistant to BS, including the model strain K12 MG1655 that produces a lipopolysaccharide (LPS) without ...
Jilong Qin, Yaoqin Hong, Waldemar Vollmer, Renato Morona, Makrina Totsika   +4 more
doaj   +1 more source

Ca2+ - Induced Structural Change of Multi-Domain Collagen Binding Segments of Collagenases ColG and ColH from Hathewaya histolytica [PDF]

, 2018
Hathewaya histolytica, previously renamed as Clostridium histolyticum, secretes at least two collagenases, ColH and ColG, that allow for degradation of extracellular matrices of animal tissue.
Ruth, Christopher Eric
core   +2 more sources

Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non‐Canonical Amino Acids

Advanced Materials, EarlyView.
A recombinant spider silk protein was functionalized by incorporating genetically encoded bio‐orthogonal reactive azido‐groups. The azido‐functionalized proteins were produced in a scalable biotechnological process, and particles, films, as well as nanofibers were established as anchorage for fully functional antibodies via site‐specific bio‐orthogonal
Claudia Lacombe, Charlotte Leonhardt, Martin Humenik, Birgit Wiltschi, Thomas Scheibel   +4 more
wiley   +1 more source

A two-step screen identifies a small molecule that disrupts membrane voltage and is effective against growing and persister gram-negative bacteria

Microbiology Spectrum
New antibiotics effective against gram-negative bacteria are difficult to discover because many small molecules are excluded by the cell envelope. There is a growing consensus that the proton motive force (PMF) represents a key target for the development
Ciara K. Asamoto, Calvin A. Ewing, Christian T. Meyer, Samual C. Allgood, Matthew J. G. Eldridge, Donald Evans, Toni A. Nagy, Grace L. Christensen, Amy L. Crooks, Daqing Jiang, Sophie Helaine, Corrella S. Detweiler   +11 more
doaj   +1 more source