Results 141 to 150 of about 396,425 (311)

Peptidoglycan LD-Transpeptidases

Antibiotics
LD-Transpeptidases (LDTs) are a widely conserved class of peptidoglycan (PG) crosslinking enzymes in bacteria. They are sometimes overlooked as they often act secondary to penicillin binding proteins (PBPs) under standard conditions.
Samuel Gastrell, Waldemar Vollmer
doaj   +1 more source

Systematic Exploration of 3D Concrete Printing Parameters for Conformal Printing on Sloped Surfaces

Advanced Robotics Research, EarlyView.
A conformal slicing algorithm is developed for robotic 3D concrete printing (3DCP) on sloped surfaces as a first step toward printing slab‐on‐grade foundations on uneven terrain. Systematic experiments quantify the effects of nozzle speed, extrusion rate, and toolpath direction on filament dimension and stability.
Paniz Farrokhsiar, Benay Gursoy, Jose Pinto Duarte   +2 more
wiley   +1 more source

Disruptions in outer membrane-peptidoglycan interactions enhance bile salt resistance in O-antigen-producing E. coli

mBio
Bile salts (BS) are antimicrobials that disrupt bacterial cell membranes and induce oxidative stress. The gut bacterium Escherichia coli is naturally resistant to BS, including the model strain K12 MG1655 that produces a lipopolysaccharide (LPS) without ...
Jilong Qin, Yaoqin Hong, Waldemar Vollmer, Renato Morona, Makrina Totsika   +4 more
doaj   +1 more source

A Low‐Cost, Handheld Optical Stiffness Sensor for Minimally Invasive Surgery

Advanced Robotics Research, EarlyView.
A novel handheld stiffness sensor is presented for real‐time tissue stiffness characterization. By simultaneously sensing contact force and tissue deformation, the device enables accurate stiffness quantification without requiring precise manual control. This approach offers a promising solution for intraoperative tumor detection and minimally invasive
Qianyu Ma, Ruxiang Jiang, Kaspar Althoefer, Nicolas Herzig, Hareesh Godaba   +4 more
wiley   +1 more source

An N4-like Caulobacter phage requires host smooth lipopolysaccharide biosynthesis for infection

Journal of Bacteriology
Caulobacter species are Alphaproteobacteria that commonly inhabit plant-associated and aquatic microbial communities. Although Caulobacter is widespread and has long served as a model for the study of bacterial cell biology, our understanding of viruses ...
Maeve McLaughlin, Katheren Barger, Charlotte Barron, Makena Fisher, Larissa Kohn, Priscilla Mac-Kittah, Aretha Fiebig, Sean Crosson   +7 more
doaj   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

A two-step screen identifies a small molecule that disrupts membrane voltage and is effective against growing and persister gram-negative bacteria

Microbiology Spectrum
New antibiotics effective against gram-negative bacteria are difficult to discover because many small molecules are excluded by the cell envelope. There is a growing consensus that the proton motive force (PMF) represents a key target for the development
Ciara K. Asamoto, Calvin A. Ewing, Christian T. Meyer, Samual C. Allgood, Matthew J. G. Eldridge, Donald Evans, Toni A. Nagy, Grace L. Christensen, Amy L. Crooks, Daqing Jiang, Sophie Helaine, Corrella S. Detweiler   +11 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

A multilayered cell envelope of a member of the Chloroflexota offers an anchoring platform for the archaellum

Frontiers in Microbiology
In a previous study, we discovered that Litorilinea aerophila, a member of the bacterial phylum Chloroflexota, had acquired a bona fide archaellum gene cluster through horizontal gene transfer from Archaea, a surprising finding given that the archaellum ...
Marie Joest, Marie Joest, Clara L. Mollat, Laura Mutschler, Marta Rodriguez-Franco, Shamphavi Sivabalasarma, Shamphavi Sivabalasarma, Friedel Drepper, Pitter F. Huesgen, Pitter F. Huesgen, Thomas Ott, Thomas Ott, Sonja-Verena Albers, Sonja-Verena Albers   +13 more
doaj   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source