Results 11 to 20 of about 11,198,861 (420)
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. [PDF]
BMC Genomics, 2018 BackgroundSingle-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. It can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully ...
Das, Diya +7 more
core +3 more sources
Fast and scalable inference of multi-sample cancer lineages. [PDF]
arXiv, 2014 Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny ...
Batzoglou, Serafim +5 more
core +6 more sources
eLife, 2018 During development, coordinated cell behaviors orchestrate tissue and organ morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful framework to elucidate the mechanisms of morphogenesis. To study the cellular basis of limb
Carsten Wolff +10 more
doaj +2 more sources
Reconstructing the Forest of Lineage Trees of Diverse Bacterial Communities Using Bio-inspired Image Analysis [PDF]
arXiv, 2017 Cell segmentation and tracking allow us to extract a plethora of cell attributes from bacterial time-lapse cell movies, thus promoting computational modeling and simulation of biological processes down to the single-cell level.
Balomenos, Athanasios D. +1 more
core +2 more sources
Asymmetry tests for Bifurcating Auto-Regressive Processes with missing data [PDF]
arXiv, 2011 We present symmetry tests for bifurcating autoregressive processes (BAR) when some data are missing. BAR processes typically model cell division data. Each cell can be of one of two types \emph{odd} or \emph{even}.
de Saporta, Benoîte +2 more
core +4 more sources
Connecting past and present: single-cell lineage tracing
Protein & Cell, 2022 Central to the core principle of cell theory, depicting cells’ history, state and fate is a fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq technologies, single-cell lineage tracing provides new opportunities to ...
Cheng Chen, Yuanxin Liao, Guangdun Peng
semanticscholar +1 more source
Three-dimensional molecular architecture of mouse organogenesis
Nature Communications, 2023 Mammalian embryos exhibit sophisticated cellular patterning that is intricately orchestrated at both molecular and cellular level. It has recently become apparent that cells within the animal body display significant heterogeneity, both in terms of their
Fangfang Qu +19 more
doaj +1 more source
BMP4 drives primed to naïve transition through PGC-like state
Nature Communications, 2022 Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate ...
Shengyong Yu +26 more
doaj +1 more source
Structure Insights Into Photosystem I Octamer From Cyanobacteria
Frontiers in Microbiology, 2022 The diversity of photosystem oligomers is essential to understanding how photosynthetic organisms adapt to light conditions. Due to its structural and physiological significance, the assembly of the PSI supercomplex has been of great interest recently in
Ming Chen +11 more
doaj +1 more source
Lung development and regeneration: newly defined cell types and progenitor status
Cell Regeneration, 2023 The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury.
Xiaogao Meng +2 more
doaj +1 more source