Results 41 to 50 of about 459,108 (316)

Directed evolution of an artificial cell lineage [PDF]

, 2007
Biological development is a complex process that mediates between genotypes, to which mutations occur, and phenotypes, on which selection acts. Properties of development can therefore have considerable impact on evolution.
Wiles, J., Geard, N., Geard, N L, Wiles, J   +3 more
core  

NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment [PDF]

, 2012
Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell types.
O'Shaughnessy, Aoife, Bertone, Paul, Latos, P, Hendrich, B, Leaford, Donna, Strouboulis, J, Brennecke, Philip, Kalkan, Tuezer, Costello, Ita, Brennecke, P, Nakagawa, Kentaro, Latos, Paulina, Hynes-Allen, Antony, Hynes-Allen, A, Behrens, A, Signolet, Jason, Mansfield, W, Kalkan, T, Reynolds, Nicola, Loos, R, Mosaku, O, Strouboulis, John, Behrens, Axel, Reynolds, N, O'Shaughnessy, A, Leaford, D, Bertone, P, Hendrich, Brian, Kalkan, Tüzer, Nakagawa, K, Loos, Remco, Humphreys, Peter, Mansfield, William, Mosaku, Olukunbi, Humphreys, P, Signolet, J   +35 more
core   +2 more sources

Cell lineage-specific mitochondrial resilience during mammalian organogenesis [PDF]

, 2023
Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression profiles involving essential mitochondrial genes emerge at an early stage in mouse development ...
Bozhilova, Lyuba V, Burr, S. P., Prater, Malwina, Diaz, Hector, Frison, M., Minczuk, M., Minczuk, Michal, Klimm, F., Simard, M. L., Glynos, Angelos, Powell, C. A., Glynos, A., Jones, Nick, Sendon, P., Nash, P., Simard, Marie-Lune, Powell, Christopher A, Charl, J., Bonekamp, N. A., Sendon, Pamella, Nie, Y., Charl, Julia, Chinnery, P. F., Bonekamp, Nina A, Frison, Michele, Nash, Pavel, Nie, Yu, Bozhilova, L. V., Klimm, Florian, Prater, M., Jones, N., Stewart, J. B., Falkenberg, Maria, Zhang, Haixin, Falkenberg, Maria,, Diaz-Maldonado, Hector,, Zhang, H. X., Burr, Stephen P, Stewart, James B, Chinnery, Patrick F   +39 more
core   +1 more source

Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies

Signal Transduction and Targeted Therapy
The upper respiratory tract is the initial site of SARS-CoV-2 infection. Nasal spike-specific secretory immunoglobulin A (sIgA) correlates with protection against Omicron breakthrough infection.
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen   +25 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Myogenic cell lineages

Developmental Biology, 1992
For many years the mechanisms by which skeletal muscles in higher vertebrates come to be composed of diverse fiber types distributed in distinctive patterns has interested cell and developmental biologists. The fiber composition of skeletal muscles varies from class to class and from muscle to muscle within the vertebrates.
openaire   +2 more sources

Advances in cell lineage reprogramming [PDF]

Science China Life Sciences, 2013
As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stem cells. However, induced pluripotent stem (iPS) cells are prepared with a complicated protocol that results in a low ...
Zhou, JunNian, Yue, Wen, Pei, XueTao
openaire   +2 more sources

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
core   +1 more source

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration [PDF]

, 2021
Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and ...
Sreenivasan, Krishnamoorthy, Segalés, Jessica, Gomez-del Arco, Pablo, Kim, Johnny, Relaix, F., Redondo, Juan Miguel, Rodríguez de la Rosa, Alejandra, Rodríguez-delaRosa, Alejandra, Muñoz Cánoves, Pura, 1962-, Arco, Pablo Gómez-Del, Relaix, Frederic, Johnny, Kim, Braun, Thomas, Munoz-Canoves, P., Gómez del Arco, Pablo, Mesquita, D., Segalés Dalmau, Jessica, Serrano Sánchez, Antonio L., Serrano, Antonio L, Rodriguez-delaRosa, A., Ianni, A., Serrano, Antonio, Gomez-del Arco, P., Braun, T., Ianni, Alessandro, Muñoz-Cánoves, Pura, Perdiguero, Eusebio, Serrano, A., Kim, J., Espejo, Isabel, Espejo, I., Sreenivasan, K., Miguel Redondo, J., Perdiguero, Eusebio, 1968-, Di Croce, Luciano, Segales, J., Di Croce, L., Perdiguero, E., Mesquita, Diana   +38 more
core   +1 more source