Results 41 to 50 of about 5,421,188 (313)

Cell Identification and Cell Lineage Analysis [PDF]

, 2011
Caenorhabditis elegans is uniquely suited to the analysis of cell lineage patterns. C. elegans has a small number of somatic cells whose position and morphology are almost invariant from animal to animal. Because C. elegans is virtually transparent, cells can be identified in live animals using a simple bright-field microscopy technique, Nomarski ...
Claudiu A, Giurumescu, Andrew D, Chisholm   +1 more
openaire   +2 more sources

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]

, 2010
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Segref, Alexandra, Johnstone, Iain L., Cabello, Juan, Ralf Schnabel, Iain L. Johnstone, Alexandra Segref, Caroline Clucas, Juan Cabello, Schnabel, Ralf, Clucas, Caroline   +9 more
core   +1 more source

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

Nature Communications, 2021
How transposable elements (TE) contribute to cell fate changes is unclear. Here, the authors generate a pipeline to quantify TE expression from single cell data.
Jiangping He, Isaac A. Babarinde, Li Sun, Shuyang Xu, Ruhai Chen, Junjie Shi, Yuanjie Wei, Yuhao Li, Gang Ma, Qiang Zhuang, Andrew P. Hutchins, Jiekai Chen   +11 more
doaj   +1 more source

Cell lineage-specific mitochondrial resilience during mammalian organogenesis [PDF]

, 2023
Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression profiles involving essential mitochondrial genes emerge at an early stage in mouse development ...
Bozhilova, Lyuba V, Burr, S. P., Prater, Malwina, Diaz, Hector, Frison, M., Minczuk, M., Minczuk, Michal, Klimm, F., Simard, M. L., Glynos, Angelos, Powell, C. A., Glynos, A., Jones, Nick, Sendon, P., Nash, P., Simard, Marie-Lune, Powell, Christopher A, Charl, J., Bonekamp, N. A., Sendon, Pamella, Nie, Y., Charl, Julia, Chinnery, P. F., Bonekamp, Nina A, Frison, Michele, Nash, Pavel, Nie, Yu, Bozhilova, L. V., Klimm, Florian, Prater, M., Jones, N., Stewart, J. B., Falkenberg, Maria, Zhang, Haixin, Falkenberg, Maria,, Diaz-Maldonado, Hector,, Zhang, H. X., Burr, Stephen P, Stewart, James B, Chinnery, Patrick F   +39 more
core   +1 more source

Myogenic cell lineages

Developmental Biology, 1992
For many years the mechanisms by which skeletal muscles in higher vertebrates come to be composed of diverse fiber types distributed in distinctive patterns has interested cell and developmental biologists. The fiber composition of skeletal muscles varies from class to class and from muscle to muscle within the vertebrates.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

p57(Kip2) imposes the reserve stem cell state of gastric chief cells

, 2022
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration.
Ju, Young Seok, Caldwell, Brianna, Wu, Szu-Hsien Sam, Choi, Eunyoung, Stange, Daniel E., Park, JinYoung, Bamford, Aileen-Diane, Kim, Somi, Kim, Jihoon, An, Yohan, Bon-kyoung Koo, Kim, Jong Kyoung, Rocha, Andreia Sofia Batista, Pilat-Carotta, Sandra, Josserand, Manon, Lee, Heetak, Han, Seungmin, Lee, Ji-Hyun, Philpott, Anna, Fink, Juergen, Szep-Bakonyi, Réka, Min, Jimin, Koo, Bon-Kyoung, Lee, Sieun, Simons, Benjamin D.   +24 more
core   +1 more source

Tracking cell lineages in 3D by incremental deep learning

eLife, 2022
Deep learning is emerging as a powerful approach for bioimage analysis. Its use in cell tracking is limited by the scarcity of annotated data for the training of deep-learning models. Moreover, annotation, training, prediction, and proofreading currently
Ko Sugawara, Çağrı Çevrim, Michalis Averof   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies

Signal Transduction and Targeted Therapy
The upper respiratory tract is the initial site of SARS-CoV-2 infection. Nasal spike-specific secretory immunoglobulin A (sIgA) correlates with protection against Omicron breakthrough infection.
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen   +25 more
doaj   +1 more source