Results 41 to 50 of about 712,102 (304)

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate [PDF]

, 2016
The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are ...
Damle, Sagar, De Medts, Jelle, De Mulder, Katrien, De Smedt, Magda, Dolens, Anne-Catherine, Durinck, Kaat, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Rothenberg, Ellen V, Speleman, Franki, Taghon, Tom, Van de Walle, Inge, Van Loocke, Wouter, Van Vlierberghe, Pieter, Vandekerckhove, Bart, Velghe, Imke, Waegemans, Els   +17 more
core   +2 more sources

Oligodendrocyte lineage cells and depression [PDF]

Molecular Psychiatry, 2020
AbstractDepression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis ...
Butian Zhou, Zhongqun Zhu, Bruce R. Ransom, Xiaoping Tong   +3 more
openaire   +2 more sources

Lineage-specific gene expression and the regulative capacities of the sea urchin embryo: a proposed mechanism [PDF]

, 1989
Three aspects of early sea urchin development are reviewed, and conclusions derived that lead to a unified concept of how the initial specifications of differential gene activity may occur in this embryo. i.
Davidson, Eric H.
core  

The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development [PDF]

, 2003
LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2° lineage vulval ...
Gupta, Bhagwati P., Sternberg, Paul W., Wang, Minqin   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation. [PDF]

, 2018
POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification.
Daigneault, Bradford W, Rajput, Sandeep, Ross, Pablo J, Smith, George W   +3 more
core   +2 more sources

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies

Signal Transduction and Targeted Therapy
The upper respiratory tract is the initial site of SARS-CoV-2 infection. Nasal spike-specific secretory immunoglobulin A (sIgA) correlates with protection against Omicron breakthrough infection.
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen   +25 more
doaj   +1 more source

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance

Frontiers in Cell and Developmental Biology, 2021
Infidelity to cell fate occurs when differentiated cells lose their original identity and either revert to a more multipotent state or transdifferentiate into a different cell type, either within the same embryonic lineage or in an entirely different one.
Antonia Malinova, Lisa Veghini, Francisco X. Real, Francisco X. Real, Francisco X. Real, Vincenzo Corbo, Vincenzo Corbo   +6 more
doaj   +1 more source

Violation of cell lineage restriction compartments in the chick hindbrain [PDF]

, 1994
Previous cell lineage studies indicate that the repeated neuromeres of the chick hindbrain, the rhombomeres, are cell lineage restriction compartments. We have extended these results and tested if the restrictions are absolute. Two different cell marking
Birgbauer, Eric, Fraser, Scott E.
core