SCLD: a stem cell lineage database for the annotation of cell types and developmental lineages [PDF]
Nucleic Acids Research, 2010 Stem cell biology has experienced explosive growth over the past decade as researchers attempt to generate therapeutically relevant cell types in the laboratory. Recapitulation of endogenous developmental trajectories is a dominant paradigm in the design of directed differentiation protocols, and attempts to guide stem cell differentiation are often ...
Edward Hemphill +6 more
openaire +2 more sources
SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]
, 2014 Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A. +7 more
core +1 more source
Oligodendrocyte lineage cells and depression [PDF]
Molecular Psychiatry, 2020 AbstractDepression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis ...
Butian Zhou +3 more
openaire +2 more sources
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
Cell Reports, 2023 Summary: Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although autophagy has been increasingly studied, how its process is precisely coordinated remains an open question. ATG14 (ATG14L/Barkor) is known to play a
Xue Shi +5 more
doaj +1 more source
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]
, 2006 Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf +23 more
core +1 more source
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985 Abstract Fixed lineages are the extreme manifestation of the interrelations between cell division pattern, spatial organization and cell differentiation occurring in embryonic development. These relationships are discussed in the light of recent new detailed descriptions of lineages, experimental perturbations and genetic analysis ...
openaire +2 more sources
Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]
, 2008 The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg +30 more
core +1 more source
Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain [PDF]
, 2012 Background: The number of neurons generated by neural stem cells is dependent upon the regulation of cell proliferation and by programmed cell death.
Heinrich Reichert +5 more
core +1 more source
Cell Regeneration, 2021 Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear.
Meijun Fu +15 more
doaj +1 more source
Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection [PDF]
, 2006 Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues.
Neta S. Zuckerman +29 more
core +1 more source