Results 11 to 20 of about 459,108 (316)

c-Jun as a one-way valve at the naive to primed interface

Cell & Bioscience, 2023
Background c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells.
Dongwei Li, Ling Luo, Lin Guo, Chuman Wu, Ran Zhang, Yuling Peng, Menghua Wu, Junqi Kuang, Yan Li, Yudan Zhang, Jun Xie, Wenxiu Xie, Rui Mao, Gang Ma, Xiuling Fu, Jiekai Chen, Andrew P. Hutchins, Duanqing Pei   +17 more
doaj   +1 more source

Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment [PDF]

, 2012
T-cell lineage specification and commitment success depends on precise temporal induction of T-lineage specific genes, as well as repression of lineage-inappropriate programs. After entry into the thymus, T-cell progenitors still retain inherited lineage
Zhang, Jingli A.
core   +1 more source

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Cell & Bioscience, 2021
Background Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling.
Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang   +5 more
doaj   +1 more source

Protocol for isolation and proteostatic analysis of sub-populations of spermatogenic cells in mouse

STAR Protocols, 2022
Summary: Spermatogenesis generates heterologous cell populations which, if not distinguished clearly, often hinder mechanistic and etiological studies.
Qianxing Zou, Lele Yang, Huayu Qi
doaj   +1 more source

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
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p57(Kip2) imposes the reserve stem cell state of gastric chief cells [PDF]

, 2022
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration.
Ju, Young Seok, Caldwell, Brianna, Wu, Szu-Hsien Sam, Choi, Eunyoung, Stange, Daniel E., Park, JinYoung, Bamford, Aileen-Diane, Kim, Somi, Kim, Jihoon, An, Yohan, Bon-kyoung Koo, Kim, Jong Kyoung, Rocha, Andreia Sofia Batista, Pilat-Carotta, Sandra, Josserand, Manon, Lee, Heetak, Han, Seungmin, Lee, Ji-Hyun, Philpott, Anna, Fink, Juergen, Szep-Bakonyi, Réka, Min, Jimin, Koo, Bon-Kyoung, Lee, Sieun, Simons, Benjamin D.   +24 more
core   +1 more source

The NuRD complex cooperates with SALL4 to orchestrate reprogramming

Nature Communications, 2023
Cell fate decision involves rewiring of the genome, but remains poorly understood at the chromatin level. Here, we report that chromatin remodeling complex NuRD participates in closing open chromatin in the early phase of somatic reprogramming.
Bo Wang, Chen Li, Jin Ming, Linlin Wu, Shicai Fang, Yi Huang, Lihui Lin, He Liu, Junqi Kuang, Chengchen Zhao, Xingnan Huang, Huijian Feng, Jing Guo, Xuejie Yang, Liman Guo, Xiaofei Zhang, Jiekai Chen, Jing Liu, Ping Zhu, Duanqing Pei   +19 more
doaj   +1 more source

Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation [PDF]

, 2012
Female mammals inactivate one of their two X-chromosomes to compensate for the difference in gene-dosage with males that have just one X-chromosome. X-chromosome inactivation is initiated by the expression of the non-coding RNA Xist, which coats the X ...
Weimar, Charlotte H. E., Weimar, C.H., Heijnen Cobi J., Kuijk Ewart W., Kuijk, E.W., Fauser, B.C., Lopes, S.M.C.D., Bart C J M Fauser, Ewart W Kuijk, Geijsen Niels, Weimar Charlotte H. E., Macklon Nick, Kuijk, Ewart W., Teklenburg, G., Fauser Bart C. J. M., Susana M Chuva de Sousa Lopes, Macklon, N., Teklenburg Gijs, Macklon, Nick, Niels Geijsen, Lopes, S.M., Weimar, C.H.E., Fauser, Bart C. J. M., Teklenburg, Gijs, Geijsen, Niels, Nick Macklon, Geijsen, N., Cobi J Heijnen, Charlotte H E Weimar, Heijnen, Cobi J., Fauser, B.C.J.M., Heijnen, C.J., Chuva de Sousa Lopes Susana M., Chuva de Sousa Lopez, Susana M., Gijs Teklenburg   +34 more
core   +1 more source

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

iScience, 2021
Summary: Maintaining proteostasis is important for animal development. How proteostasis influences spermatogenesis that generates male gametes, spermatozoa, is not clear.
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi   +5 more
doaj   +1 more source

Oligodendrocyte lineage cells and depression [PDF]

Molecular Psychiatry, 2020
AbstractDepression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis ...
Butian Zhou, Zhongqun Zhu, Bruce R. Ransom, Xiaoping Tong   +3 more
openaire   +2 more sources