Results 11 to 20 of about 712,102 (304)

T‐cell lineage determination [PDF]

Immunological Reviews, 2010
Summary:  T cells originate from hematopoietic stem cells (HSCs) in the bone marrow but complete their development in the thymus. HSCs give rise to a variety of non‐renewing hematopoietic progenitors, among which a rare subset migrates to the thymus via the bloodstream.
Qi, Yang, J, Jeremiah Bell, Avinash, Bhandoola   +2 more
openaire   +2 more sources

Monocyte–Macrophage Lineage Cell Fusion

International Journal of Molecular Sciences, 2022
Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs).
Kloc, Malgorzata, Subuddhi, Arijita, Uosef, Ahmed, Kubiak, Jacek, Ghobrial, Rafik M.   +4 more
openaire   +3 more sources

c-Jun as a one-way valve at the naive to primed interface

Cell & Bioscience, 2023
Background c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells.
Dongwei Li, Ling Luo, Lin Guo, Chuman Wu, Ran Zhang, Yuling Peng, Menghua Wu, Junqi Kuang, Yan Li, Yudan Zhang, Jun Xie, Wenxiu Xie, Rui Mao, Gang Ma, Xiuling Fu, Jiekai Chen, Andrew P. Hutchins, Duanqing Pei   +17 more
doaj   +1 more source

Lineage dynamics of murine pancreatic development at single-cell resolution. [PDF]

, 2018
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time.
Byrnes, Lauren E, Gilchrist, Caroline L, Knox, Sarah M, Meyer, Nathaniel P, Sneddon, Julie B, Subramaniam, Meena, Tward, Aaron D, Wong, Daniel M, Ye, Chun J   +8 more
core   +2 more sources

The NuRD complex cooperates with SALL4 to orchestrate reprogramming

Nature Communications, 2023
Cell fate decision involves rewiring of the genome, but remains poorly understood at the chromatin level. Here, we report that chromatin remodeling complex NuRD participates in closing open chromatin in the early phase of somatic reprogramming.
Bo Wang, Chen Li, Jin Ming, Linlin Wu, Shicai Fang, Yi Huang, Lihui Lin, He Liu, Junqi Kuang, Chengchen Zhao, Xingnan Huang, Huijian Feng, Jing Guo, Xuejie Yang, Liman Guo, Xiaofei Zhang, Jiekai Chen, Jing Liu, Ping Zhu, Duanqing Pei   +19 more
doaj   +1 more source

Protocol for isolation and proteostatic analysis of sub-populations of spermatogenic cells in mouse

STAR Protocols, 2022
Summary: Spermatogenesis generates heterologous cell populations which, if not distinguished clearly, often hinder mechanistic and etiological studies.
Qianxing Zou, Lele Yang, Huayu Qi
doaj   +1 more source

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Cell & Bioscience, 2021
Background Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling.
Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang   +5 more
doaj   +1 more source

Molecular recording of mammalian embryogenesis. [PDF]

, 2019
Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt, Chan, Michelle M, Grosswendt, Stefanie, Jones, Matthew G, Jost, Marco, Khodaverdian, Alex, Kretzmer, Helene, Meissner, Alexander, Norman, Thomas M, Quinn, Jeffrey J, Smith, Zachary D, Weissman, Jonathan S, Yang, Dian, Yosef, Nir   +13 more
core   +2 more sources

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. [PDF]

, 2014
BackgroundIdentification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.ResultsWe demonstrate that conditional ...
Band, Hamid, Band, Vimla, Edwards, Emily, Kopp, Janel L, Malhotra, Gautam K, Naramura, Mayumi, Sander, Maike, Zhao, Xiangshan   +7 more
core   +2 more sources

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

iScience, 2021
Summary: Maintaining proteostasis is important for animal development. How proteostasis influences spermatogenesis that generates male gametes, spermatozoa, is not clear.
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi   +5 more
doaj   +1 more source