Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny [PDF]
, 2012 The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology.
Calaminus, Simon +34 more
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SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]
, 2014 Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A. +7 more
core +1 more source
Diversity Among Cyanobacterial Photosystem I Oligomers
Frontiers in Microbiology, 2022 Unraveling the oligomeric states of the photosystem I complex is essential to understanding the evolution and native mechanisms of photosynthesis. The molecular composition and functions of this complex are highly conserved among cyanobacteria, algae ...
Ming Chen +10 more
doaj +1 more source
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]
, 2006 Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf +23 more
core +1 more source
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
Cell Reports, 2023 Summary: Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although autophagy has been increasingly studied, how its process is precisely coordinated remains an open question. ATG14 (ATG14L/Barkor) is known to play a
Xue Shi +5 more
doaj +1 more source
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985 Abstract Fixed lineages are the extreme manifestation of the interrelations between cell division pattern, spatial organization and cell differentiation occurring in embryonic development. These relationships are discussed in the light of recent new detailed descriptions of lineages, experimental perturbations and genetic analysis ...
openaire +2 more sources
Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity [PDF]
, 2019 Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J +17 more
core +1 more source
SCLD: a stem cell lineage database for the annotation of cell types and developmental lineages [PDF]
Nucleic Acids Research, 2010 Stem cell biology has experienced explosive growth over the past decade as researchers attempt to generate therapeutically relevant cell types in the laboratory. Recapitulation of endogenous developmental trajectories is a dominant paradigm in the design of directed differentiation protocols, and attempts to guide stem cell differentiation are often ...
Edward Hemphill +6 more
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Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]
, 2008 The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg +30 more
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Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain [PDF]
, 2012 Background: The number of neurons generated by neural stem cells is dependent upon the regulation of cell proliferation and by programmed cell death.
Heinrich Reichert +5 more
core +1 more source