Results 51 to 60 of about 5,421,188 (313)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
core   +1 more source

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

Scientific Reports
Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality.
Wu Haoyu, Liu Meiqin, Sun Jiaoyang, Hong Guangliang, Lin Haofeng, Chen Pan, Quan Xiongzhi, Wu Kaixin, Hu Mingli, Yang Xuejie, Ingo Lämmermann, Johannes Grillari, Shi Zhengli, Chen Jiekai, Wu Guangming   +14 more
doaj   +1 more source

Initial characterization of gap phase introduction in every cell cycle of C. elegans embryogenesis

Frontiers in Cell and Developmental Biology, 2022
Early embryonic cell cycles usually alternate between S and M phases without any gap phase. When the gap phases are developmentally introduced in various cell types remains poorly defined especially during embryogenesis.
Ming-Kin Wong, Vincy Wing Sze Ho, Xiaotai Huang, Xiaotai Huang, Lu-Yan Chan, Dongying Xie, Runsheng Li, Xiaoliang Ren, Guoye Guan, Yiming Ma, Boyi Hu, Boyi Hu, Hong Yan, Zhongying Zhao, Zhongying Zhao   +14 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment [PDF]

, 2012
Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell types.
O'Shaughnessy, Aoife, Bertone, Paul, Latos, P, Hendrich, B, Leaford, Donna, Strouboulis, J, Brennecke, Philip, Kalkan, Tuezer, Costello, Ita, Brennecke, P, Nakagawa, Kentaro, Latos, Paulina, Hynes-Allen, Antony, Hynes-Allen, A, Behrens, A, Signolet, Jason, Mansfield, W, Kalkan, T, Reynolds, Nicola, Loos, R, Mosaku, O, Strouboulis, John, Behrens, Axel, Reynolds, N, O'Shaughnessy, A, Leaford, D, Bertone, P, Hendrich, Brian, Kalkan, Tüzer, Nakagawa, K, Loos, Remco, Humphreys, Peter, Mansfield, William, Mosaku, Olukunbi, Humphreys, P, Signolet, J   +35 more
core   +2 more sources

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers. [PDF]

, 2020
Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in ...
Dive, Caroline, Rubin, Mark Andrew, Bristow, Robert G, Imielinski, Marcin, Thienger, Phillip Dominik   +4 more
core   +2 more sources

Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts

Nature Communications
Master transcription factors (MTFs) are key regulators in cell fate determination. However, an approach to profile MTF’s direct transcriptional targets together with their associated RNA-binding proteins (RBPs), is still lacking.
Mingqiang Deng, Dongmei He, Xiwei Wang, Yuting Yuan, Lishen Wang, Yanlin Hou, Qiuyue Zhu, Chuanman Zhou, Zhibiao Mai, Yulong Zhang, Zhengwen Nie, Yuling Song, Qiongfang Wu, Luyao Pan, Bei Dong, Zhi Xiong, Duo Li, Dongjun Liu, Jinxin Xu, Dajiang Qin, Hui Zheng, Yu Zhao, Peng Tang, Jinkai Wang, Cristin Print, Ralf Jauch, Wensheng Zhang, Guangming Wu, Xichen Bao   +28 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source