Results 51 to 60 of about 712,102 (304)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. [PDF]

, 2018
BackgroundSingle-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. It can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully ...
Das, Diya, Dudoit, Sandrine, Fletcher, Russell B, Ngai, John, Purdom, Elizabeth, Risso, Davide, Street, Kelly, Yosef, Nir   +7 more
core   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts

Nature Communications
Master transcription factors (MTFs) are key regulators in cell fate determination. However, an approach to profile MTF’s direct transcriptional targets together with their associated RNA-binding proteins (RBPs), is still lacking.
Mingqiang Deng, Dongmei He, Xiwei Wang, Yuting Yuan, Lishen Wang, Yanlin Hou, Qiuyue Zhu, Chuanman Zhou, Zhibiao Mai, Yulong Zhang, Zhengwen Nie, Yuling Song, Qiongfang Wu, Luyao Pan, Bei Dong, Zhi Xiong, Duo Li, Dongjun Liu, Jinxin Xu, Dajiang Qin, Hui Zheng, Yu Zhao, Peng Tang, Jinkai Wang, Cristin Print, Ralf Jauch, Wensheng Zhang, Guangming Wu, Xichen Bao   +28 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche

Cell Regeneration
The interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC ...
Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen   +12 more
doaj   +1 more source

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos [PDF]

Open Biology, 2013
Lineage specification in the preimplantation mouse embryo is a regulative process. Thus, it has been difficult to ascertain whether segregation of the inner-cell-mass (ICM) into precursors of the pluripotent epiblast (EPI) and the differentiating ...
Samantha A. Morris, Sarah J. L. Graham, Agnieszka Jedrusik, Magdalena Zernicka-Goetz   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

Scientific Reports
Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality.
Wu Haoyu, Liu Meiqin, Sun Jiaoyang, Hong Guangliang, Lin Haofeng, Chen Pan, Quan Xiongzhi, Wu Kaixin, Hu Mingli, Yang Xuejie, Ingo Lämmermann, Johannes Grillari, Shi Zhengli, Chen Jiekai, Wu Guangming   +14 more
doaj   +1 more source

Advances in cell lineage reprogramming [PDF]

Science China Life Sciences, 2013
As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stem cells. However, induced pluripotent stem (iPS) cells are prepared with a complicated protocol that results in a low ...
Zhou, JunNian, Yue, Wen, Pei, XueTao
openaire   +2 more sources