Results 71 to 80 of about 459,108 (316)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

FEBS Open Bio
Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2.
Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Transcriptional convergence of oligodendrocyte lineage progenitors during development [PDF]

, 2018
Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at ...
Munguba, Hermany,, Taft, Ryan James,, Hjerling-Leffler, Jens, Castelo-Branco, Goncalo, Meijer, Mandy, Falc\ue3o, Ana Mendanha, Vanichkina, Darya Pavlovna,, Marques, Sueli, Falcao, Ana Mendanha,, Björklund, Åsa K., Hjerling-Leffler, Jens,, Vanichkina, Darya Pavlovna, Munguba, Hermany, Marques, Sueli,, Giacomello, Stefania,, Falcao, Ana Mendanha, Castelo-Branco, Goncalo,, Björklund, Åsa Kristina,, Väremo, Leif,, Meijer, Mandy,, Bj\uf6rklund, \uc5sa Kristina, Floriddia, Elisa Mariagrazia,, Björklund, Åsa K.,, Floriddia, Elisa Mariagrazia, Castelo-Branco, Gon\ue7alo, Wigge, Leif,, van Bruggen, David,, Taft, Ryan James, Varemo, Leif, Wigge, Leif, van Bruggen, David, Giacomello, Stefania, Bjorklund, Asa Kristina   +32 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development [PDF]

, 2019
During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal analyses to reveal lineage trees and molecular signals underlying early ...
Mich, John, Thomsen, Elliot, Phillips, John, Ramanathan, Sharad, Shapovalova, Nadiya, Glass, Ian, Levi, Boaz, Thompson, Carol, Tait, Leah, Bort, Susan, Ku, Sherman, Mulholland, Heather, Wang, Yanling, Martinez, Refugio A., Nelson, Angelique, Grimley, Joshua, Jayabalu, Anu, Smith, Michael, Ye, Chaoyang, Melton, Samuel, Yao, Zizhen, Ngo, N. Kiet, Hodge, Rebecca, Krostag, Anne-Rachel, Furchtgott, Leon, Gregor, Ben, May, Ryan, Fuqua, Margaret, Shehata, Soraya, Menon, Vilas, Kaykas, Ajamete, Yao, Shuyuan   +31 more
core   +1 more source

CDK14 regulates the development and repair of lung

Cell Death Discovery
Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. However, the function of CDK14 during organ development and regeneration has not been investigated in ...
Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen   +15 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

Frontiers in Immunology
BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the ...
Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen   +20 more
doaj   +1 more source