Results 71 to 80 of about 5,421,188 (313)

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation [PDF]

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis [PDF]

, 2022
Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids (PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC)
한현호
core   +1 more source

Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy

Clinical and Translational Medicine
Background Immunotherapy has emerged as a crucial treatment modality for solid tumours, yet tumours often evade immune surveillance. There is an imperative to uncover novel immune regulators that can boost tumour immunogenicity and increase the efficacy ...
Kaixin Wu, Sa Li, Guangliang Hong, Hongzhi Dong, Tongke Tang, He Liu, Lingmei Jin, Siyuan Lin, Jingyun Ji, Mingli Hu, Shuntian Chen, Haoyuan Wu, Guanzheng Luo, Haoyuan Wu, Xiangqian Kong, Jiekai Chen, Jiangping He, Hongling Wu   +17 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Retrospective cell lineage reconstruction in humans by using short tandem repeats

, 2022
Art. 100054, 16 S.Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals.
Greindl-Junghans, J., Levy, R., Ben Arie, A., Czyz, Z.T., Ghosh, M.S., Klein, C.A., Shapiro, E., Biezuner, T., Marx, Z., Oron, B., Raz, O., Huber, S., Chapal-Ilani, N., Milo, L., Werner-Klein, M., Onn, A., Berman, V., Halaban, R., Rom, G., Adar, R., Tao, L., Amir, S.   +21 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Methodology for reconstructing early zebrafish development from in vivo multiphoton microscopy [PDF]

, 2012
Investigating cell dynamics during early zebrafish embryogenesis requires specific image acquisition and analysis strategies. Multiharmonic microscopy, i.e., second- and third-harmonic generations, allows imaging cell divisions and cell membranes in ...
A. Santos, T. Savy, N. Olivier, Luengo-Oroz, Miguel Angel, M. Ledesma-Carbayo, Bourgine, Paul, Olivier, Nicolas, D. Debarre, Savy, Thierry, Debarre, Delphine, Rubio-Guivernau, José L., P. Bourgine, Santos Lleo, Andres de, Faure, Emmanuel, Luengo Oroz, Miguel Ángel, Ledesma Carbayo, María Jesús, M. A. Luengo-Oroz, Pastor Escuredo, David, E. Faure, Duloquin, Louise, J. L. Rubio-Guivernau, N. Peyrieras, Ledesma-Carbayo, María Jesús, Santos, Andrés, E. Beaurepaire, Peyrieras, Nadine, Pastor-Escuredo, David, D. Pastor, L. Duloquin, Rubio Guivernau, José Luis, Beaurepaire, Emmanuel   +30 more
core   +1 more source

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

FEBS Open Bio
Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2.
Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Advances in cell lineage reprogramming [PDF]

Science China Life Sciences, 2013
As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stem cells. However, induced pluripotent stem (iPS) cells are prepared with a complicated protocol that results in a low ...
Zhou, JunNian, Yue, Wen, Pei, XueTao
openaire   +2 more sources