Results 91 to 100 of about 712,102 (304)

Differential expression of conserved germ line markers and delayed segregation of male and female primordial germ cells in a hermaphrodite, the leech helobdella. [PDF]

, 2013
In sexually reproducing animals, primordial germ cells (PGCs) are often set aside early in embryogenesis, a strategy that minimizes the risk of genomic damage associated with replication and mitosis during the cell cycle.
Cho, Sung-Jin, Vallès, Yvonne, WEISBLAT, David A.   +2 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Single-cell analysis reveals T cell dysfunction driven by macrophages and differential expression of transposable elements in severe COVID-19 patients

Heliyon
The vastly spreading COVID-19 pneumonia is caused by SARS-CoV-2. Lymphopenia and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation at cellular and molecular levels remains largely undefined.
Airu Zhu, Liang Zhou, Zhao Chen, Dongdong Liu, Huijian Feng, Baomei Cai, Xinwen Chen, Jincun Zhao, Jingxian Zhao, Jiekai Chen, Manshu Li, Jiangping He   +11 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions

EMBO Reports
CTNNA1, a multifunctional protein that localizes at both the plasma membrane and the cytosol, plays crucial roles in actin dynamics regulation, cell-to-cell and cell-to-the extracellular matrix (ECM) adhesions and tumor suppression.
Dan Xiang, Wenfeng Wu, Ruona Shi, Xiaoxiao Tang, Xiaofei Zhang   +4 more
doaj   +1 more source

Generation of a PPM1A-deficient human induced pluripotent stem cell line using CRISPR-Cas9 technology

Stem Cell Research
PPM1A is a member of the serine/threonine protein phosphatase family. It can bind to a variety of proteins to dephosphorylate them, and extensively regulates many life activities such as cell growth, cell stress, immune response, and tumor formation ...
Xinrui Guo, Kui Zhao, Yanqi Zhang, Tiancheng Zhou, Guangjin Pan   +4 more
doaj   +1 more source

Plectus - a stepping stone in embryonic cell lineage evolution of nematodes

EvoDevo, 2012
Background Recent studies have challenged the widespread view that the pattern of embryogenesis found in Caenorhabditis elegans (clade 9) is characteristic of nematodes in general.
Schulze Jens, Houthoofd Wouter, Uenk Jana, Vangestel Sandra, Schierenberg Einhard   +4 more
doaj   +1 more source

Cell lineage: Compartments and Capricious [PDF]

Current Biology, 2001
Until recently, little was known about the mechanisms that prevent cell migration across compartment boundaries in Drosophila. A new report suggests that the lineage restriction between the dorsal and ventral compartments of the developing wing relies in part on the transmembrane proteins, Capricious and Tartan.
openaire   +2 more sources

Using genotype abundance to improve phylogenetic inference

, 2018
Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times.
DeWitt III, William S., Matsen IV, Frederick A., Mesin, Luka, Minin, Vladimir N., Victora, Gabriel D.   +4 more
core   +1 more source