Results 101 to 110 of about 459,108 (316)

UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions

EMBO Reports
CTNNA1, a multifunctional protein that localizes at both the plasma membrane and the cytosol, plays crucial roles in actin dynamics regulation, cell-to-cell and cell-to-the extracellular matrix (ECM) adhesions and tumor suppression.
Dan Xiang, Wenfeng Wu, Ruona Shi, Xiaoxiao Tang, Xiaofei Zhang   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell types [PDF]

, 2010
Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell ...
A Boquest (13711165), A Sorensen (13711159), L Ährlund-Richter (13711168), S Stice (13711171), F West (13331970), P Collas (13636555), S Timoskainen (13636552), K Vekterud (13711162)   +7 more
core  

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]

, 2014
Peer ...
Findlay, Amy S., Ouyang, Zhufeng, Zakrewska, Ewa, Kuan, Soh-Leh, Durward, Elaine, Nakamoto, Masaru, Findlay, Amy, Zakrzewska, Ewa, Nakamoto, Chizu, Kuan, Soh Leh, Endo, Takuma   +10 more
core   +1 more source

Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a

Cell Reports
Summary: Single-cell lineage tracing based on CRISPR-Cas9 gene editing enables the simultaneous linkage of cell states and lineage history at a high resolution.
Cheng Chen, Yuanxin Liao, Miao Zhu, Li Wang, Xinran Yu, Meishi Li, Guangdun Peng   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma [PDF]

A subset of patients with IDH-mutant glioma respond to inhibitors of mutant IDH (IDHi), yet the molecular underpinnings of such responses are not understood.
Spitzer, Avishay, Fortin, Jerome, Suvà, Mario L., Mak, Tak W., Wen, Patrick Y., Weisman, Hannah R., Lee Servis, Rachel, Lee, Christine K., Nomura, Masashi, Pisano, Will, Jucht, Alexander, Landau, Dan A., Touat, Mehdi, Arrillaga-Romany, Isabel, Ligon, Keith L., Miller, Julie J., Lee, John J.Y., Louis, David N., Cahill, Daniel P., Fung, Jeremy Man, Wakimoto, Hiroaki, Gonzalez Castro, L. Nicolas, Mylvaganam, Ravindra, Sanson, Marc, Nagashima, Hiroaki, Raviram, Ramya, Gritsch, Simon, Tirosh, Itay, Druck, Nicholas, Chanoch-Myers, Rony   +29 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster [PDF]

, 2010
Much of our knowledge on hematopoiesis, hematopoietic compartments, hematopoietic cell lineages and immunity has been derived from studies on the vertebrate immune system.
Márkus, Róbert, Csordás, Gábor, Andó, István, Kurucz, Éva, Jankovics, Ferenc, Honti, Viktor   +5 more
core   +1 more source

Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

eLife, 2019
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional ...
Luis Sánchez-Guardado, Carlos Lois
doaj   +1 more source