Results 81 to 90 of about 459,108 (316)

Development of Dendritic-Cell Lineages [PDF]

Immunity, 2007
Dendritic cells (DCs) are a heterogenous population of bone-marrow-derived immune cells. Although all DCs share a common ability to process and present antigen to naive T cells for the initiation of an immune response, they differ in surface markers, migratory patterns, localization, and cytokine production. DCs were originally considered to be myeloid
Wu, Li, Liu, Yong-Jun
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Injury activates transient olfactory stem cell states with diverse lineage capacities [PDF]

, 2017
Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques,
Sanchez, Michael A, Ngai, John, Nir Yosef, Yoon Gi Choi, Gadye, Levi, Purdom, Elizabeth, Wagner, Allon, Choi, Yoon Gi, Risso, Davide, Michael B. Cole, Levi Gadye, Ariane Baudhuin, Fletcher, Russell B, Davide Risso, Street, Kelly, John Ngai, Michael A. Sanchez, Diya Das, Yosef, Nir, Dudoit, Sandrine, Baudhuin, Ariane, Sandrine Dudoit, Das, Diya, Kelly Street, Elizabeth Purdom, Cole, Michael B, Russell B. Fletcher, Allon Wagner   +27 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. [PDF]

, 2005
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.
Luciano Conti, Thorsten Gorba (59561), Mauro Toselli, Biella, G, Sanzone Sveva, Toselli, M, Austin Smith, Reitano Erika, Reitano, E, T. Gorba, Smith Austin, Steven M Pollard, E. Reitano, Sveva Sanzone (59566), BIELLA, GERARDO ROSARIO, Smith A., Reitano E, Gorba T, Ying Ql, Ying Qi-Long, Conti, L, Conti L, Sun Y, Sanzone, S, L. Conti, S. Sanzone, Toselli Mauro, Steven M Pollard (59560), Qi-Long Ying (59567), Q. L. Ying, Cattaneo Elena, Pollard, S M, Luciano Conti (59559), Y. R. Sun, Pollard Sm, Cattaneo E, Sun, Y R, Sveva Sanzone, Smith, A, Erika Reitano, Pollard Steven M, Yirui Sun, TOSELLI, MAURO GIUSEPPE, Thorsten Gorba, Ying, Q L, Yirui Sun (59565), Ying, QL, Conti Luciano, Gerardo Biella, Sun Yirui, Elena Cattaneo, E. Cattaneo, Mauro Toselli (59563), Austin Smith (59569), Qi-Long Ying, Biella Gerardo, Erika Reitano (59562), Pollard, SM, Cattaneo, E, Sanzone S, G. Biella, Gerardo Biella (59564), Gorba Thorsten, Gorba, T, A. Smith, Elena Cattaneo (59568), Sun, Y, S. M. Pollard, M. Toselli   +68 more
core   +2 more sources

High-resolution mapping of single cells in spatial context

Nature Communications
Spatially resolved transcriptomic technologies have emerged as pivotal tools for elucidating molecular regulation and cellular interplay within the intricate tissue microenvironment, but hampered by insufficient gene recovery or challenges in achieving ...
Jincan Ke, Jian Xu, Jia Liu, Yumeng Yang, Chenkai Guo, Bingbing Xie, Guizhong Cui, Guangdun Peng, Shengbao Suo   +8 more
doaj   +1 more source

A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy

Journal of Advanced Research
Introduction: Traumatic Brain Injury (TBI) usually leads to substantial mortality and disability among adult populations. Neural progenitor cells (NPCs) transplantation exhibits great potential in TBI treatment.
Di Zhang, Jun Chen, Huaisong Lin, Min Zhou, Jinfei Hou, Wei Sun, Qi Xing, Wenhao Huang, Yanqi Zhang, Yiping Guo, Chunhua Liu, Aiping Lin, Cong Zhang, Yuhua Huang, Li-En Tao, Bowen Xie, Jian Zhang, Qianyu Chen, Yongli Shan, Yanling Zhu, Guangjin Pan, Lin-Ping Wu   +21 more
doaj   +1 more source

Cell lineage: Compartments and Capricious [PDF]

Current Biology, 2001
Until recently, little was known about the mechanisms that prevent cell migration across compartment boundaries in Drosophila. A new report suggests that the lineage restriction between the dorsal and ventral compartments of the developing wing relies in part on the transmembrane proteins, Capricious and Tartan.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the Origin of Cells

Journal of Developmental Biology, 2015
While non-blood cell lineage has been studied for decades by developmental biologists, only recently has it been considered in disease. This is partly due to a lack of suitable reagents in experimental models, but it is also the result of a failure to ...
Robert W. Dettman
doaj   +1 more source