Results 81 to 90 of about 712,102 (304)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]

, 2014
Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation.
Capra, John A., Kostka, Dennis
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

Frontiers in Immunology
BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the ...
Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen   +20 more
doaj   +1 more source

Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

eLife, 2017
Reconstructing the lineage of cells is central to understanding how the wide diversity of cell types develops. Here, we provide the neurosensory lineage reconstruction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo over ...
Sylvia Dyballa, Thierry Savy, Philipp Germann, Karol Mikula, Mariana Remesikova, Róbert Špir, Andrea Zecca, Nadine Peyriéras, Cristina Pujades   +8 more
doaj   +1 more source

Reprogramming Committed B Lineage Cells [PDF]

Cell, 2004
It is generally assumed that once a cell commits to a certain lineage it no longer can change its fate. A new study in this issue of Cell provides compelling evidence that committed mature B lineage cells can be reprogrammed to become macrophages.
openaire   +2 more sources

Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias. [PDF]

, 2016
Long noncoding RNAs (lncRNAs) are non-proten-coding transcripts of more than 200 nucleotides generated by RNA polymerase II and their expressions are tightly regulated in cell type specific- and/or cellular differential stage specific- manner.
Croce, Carlo M, Kipps, Thomas J, Moshiri, Farzaneh, Nakamura, Tatsuya, Ngankeu, Apollinaire, Sattari, Arash, Siddiqui, Hasan   +6 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

High-resolution mapping of single cells in spatial context

Nature Communications
Spatially resolved transcriptomic technologies have emerged as pivotal tools for elucidating molecular regulation and cellular interplay within the intricate tissue microenvironment, but hampered by insufficient gene recovery or challenges in achieving ...
Jincan Ke, Jian Xu, Jia Liu, Yumeng Yang, Chenkai Guo, Bingbing Xie, Guizhong Cui, Guangdun Peng, Shengbao Suo   +8 more
doaj   +1 more source

A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy

Journal of Advanced Research
Introduction: Traumatic Brain Injury (TBI) usually leads to substantial mortality and disability among adult populations. Neural progenitor cells (NPCs) transplantation exhibits great potential in TBI treatment.
Di Zhang, Jun Chen, Huaisong Lin, Min Zhou, Jinfei Hou, Wei Sun, Qi Xing, Wenhao Huang, Yanqi Zhang, Yiping Guo, Chunhua Liu, Aiping Lin, Cong Zhang, Yuhua Huang, Li-En Tao, Bowen Xie, Jian Zhang, Qianyu Chen, Yongli Shan, Yanling Zhu, Guangjin Pan, Lin-Ping Wu   +21 more
doaj   +1 more source