Results 81 to 90 of about 5,421,188 (313)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Analysis of the "engrailed"-expressing neuroblast lineages in "Drosophila" brain development [PDF]

, 2009
The segment polarity gene engrailed (en) encodes a homeodomain transcription factor which is expressed in metamerically reiterated stripes in the embryonic neuroectoderm, in some primary neuroblasts and their progeny; usually located at the posterior ...
Kumar, Abhilasha
core   +1 more source

CDK14 regulates the development and repair of lung

Cell Death Discovery
Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. However, the function of CDK14 during organ development and regeneration has not been investigated in ...
Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen   +15 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Transcriptional convergence of oligodendrocyte lineage progenitors during development [PDF]

, 2018
Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at ...
Munguba, Hermany,, Taft, Ryan James,, Hjerling-Leffler, Jens, Castelo-Branco, Goncalo, Meijer, Mandy, Falc\ue3o, Ana Mendanha, Vanichkina, Darya Pavlovna,, Marques, Sueli, Falcao, Ana Mendanha,, Björklund, Åsa K., Hjerling-Leffler, Jens,, Vanichkina, Darya Pavlovna, Munguba, Hermany, Marques, Sueli,, Giacomello, Stefania,, Falcao, Ana Mendanha, Castelo-Branco, Goncalo,, Björklund, Åsa Kristina,, Väremo, Leif,, Meijer, Mandy,, Bj\uf6rklund, \uc5sa Kristina, Floriddia, Elisa Mariagrazia,, Björklund, Åsa K.,, Floriddia, Elisa Mariagrazia, Castelo-Branco, Gon\ue7alo, Wigge, Leif,, van Bruggen, David,, Taft, Ryan James, Varemo, Leif, Wigge, Leif, van Bruggen, David, Giacomello, Stefania, Bjorklund, Asa Kristina   +32 more
core   +1 more source

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

Frontiers in Immunology
BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the ...
Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen   +20 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland

, 2023
The development of the mouse salivary gland involves a tip-driven process of branching morphogenesis that takes place in concert with differentiation into acinar, myoepithelial, and ductal (basal and luminal) sub -line-ages.
Bonkyoung Koo, Bordeu, Ignacio, Han, Seungmin, Alcolea, Maria P., Waheed, Zahra, Chatzeli, Lemonia, Simons, Benjamin D., Bisetto, Sara   +7 more
core   +1 more source

High-resolution mapping of single cells in spatial context

Nature Communications
Spatially resolved transcriptomic technologies have emerged as pivotal tools for elucidating molecular regulation and cellular interplay within the intricate tissue microenvironment, but hampered by insufficient gene recovery or challenges in achieving ...
Jincan Ke, Jian Xu, Jia Liu, Yumeng Yang, Chenkai Guo, Bingbing Xie, Guizhong Cui, Guangdun Peng, Shengbao Suo   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source