Results 61 to 70 of about 459,108 (316)
Lineage-specific S-cell extinction time determines linage size. [PDF]
(Shaded areas show the range between the 2.5% and 97.5% quantile across 5 billion simulations). (A) Lineage-specific growth trajectories under the SAN model stratified by the lineage’s S-cell extinction time TS.
Arndt von Haeseler (8213) +5 more
core +1 more source
Methodology for reconstructing early zebrafish development from in vivo multiphoton microscopy [PDF]
, 2012 Investigating cell dynamics during early zebrafish embryogenesis requires specific image acquisition and analysis strategies. Multiharmonic microscopy, i.e., second- and third-harmonic generations, allows imaging cell divisions and cell membranes in ...
A. Santos +30 more
core +2 more sources
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers. [PDF]
, 2020 Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in ...
Thienger, Phillip D. +7 more
core +1 more source
H3K36 methylation maintains cell identity by regulating opposing lineage programmes [PDF]
, 2023 The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities across diverse developmental ...
Wong, Lai Ping +30 more
core +1 more source
Cell RegenerationThe COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu +7 more
doaj +1 more source
Initial characterization of gap phase introduction in every cell cycle of C. elegans embryogenesis
Frontiers in Cell and Developmental Biology, 2022 Early embryonic cell cycles usually alternate between S and M phases without any gap phase. When the gap phases are developmentally introduced in various cell types remains poorly defined especially during embryogenesis.
Ming-Kin Wong +14 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy
Clinical and Translational MedicineBackground Immunotherapy has emerged as a crucial treatment modality for solid tumours, yet tumours often evade immune surveillance. There is an imperative to uncover novel immune regulators that can boost tumour immunogenicity and increase the efficacy ...
Kaixin Wu +17 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Analysis of the "engrailed"-expressing neuroblast lineages in "Drosophila" brain development [PDF]
, 2009 The segment polarity gene engrailed (en) encodes a homeodomain transcription factor which is expressed in metamerically reiterated stripes in the embryonic neuroectoderm, in some primary neuroblasts and their progeny; usually located at the posterior ...
Kumar, Abhilasha
core +1 more source