Results 61 to 70 of about 5,421,188 (313)

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source

Directed evolution of an artificial cell lineage

, 2007
Biological development is a complex process that mediates between genotypes, to which mutations occur, and phenotypes, on which selection acts. Properties of development can therefore have considerable impact on evolution.
Geard, N L, Wiles, J
core   +1 more source

A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche

Cell Regeneration
The interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC ...
Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen   +12 more
doaj   +1 more source

A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

eLife, 2021
The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly.
Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Heather Q Pollington, Ashok Litwin-Kumar, Albert Cardona, James W Truman, Chris Q Doe   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration [PDF]

, 2021
Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and ...
Sreenivasan, Krishnamoorthy, Segalés, Jessica, Gomez-del Arco, Pablo, Kim, Johnny, Relaix, F., Redondo, Juan Miguel, Rodríguez de la Rosa, Alejandra, Rodríguez-delaRosa, Alejandra, Muñoz Cánoves, Pura, 1962-, Arco, Pablo Gómez-Del, Relaix, Frederic, Johnny, Kim, Braun, Thomas, Munoz-Canoves, P., Gómez del Arco, Pablo, Mesquita, D., Segalés Dalmau, Jessica, Serrano Sánchez, Antonio L., Serrano, Antonio L, Rodriguez-delaRosa, A., Ianni, A., Serrano, Antonio, Gomez-del Arco, P., Braun, T., Ianni, Alessandro, Muñoz-Cánoves, Pura, Perdiguero, Eusebio, Serrano, A., Kim, J., Espejo, Isabel, Espejo, I., Sreenivasan, K., Miguel Redondo, J., Perdiguero, Eusebio, 1968-, Di Croce, Luciano, Segales, J., Di Croce, L., Perdiguero, E., Mesquita, Diana   +38 more
core   +1 more source

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

Cell Regeneration
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen   +7 more
doaj   +1 more source

An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

eLife, 2022
In recent years, live-imaging techniques have been developed for the adult midgut of Drosophila melanogaster that allow temporal characterization of key processes involved in stem cell and tissue homeostasis.
Marco Marchetti, Chenge Zhang, Bruce A Edgar   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source