Results 121 to 130 of about 459,108 (316)

Multi-view light-sheet imaging and tracking with the MaMuT software reveals the cell lineage of a direct developing arthropod limb

eLife, 2018
During development, coordinated cell behaviors orchestrate tissue and organ morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful framework to elucidate the mechanisms of morphogenesis. To study the cellular basis of limb
Carsten Wolff, Jean-Yves Tinevez, Tobias Pietzsch, Evangelia Stamataki, Benjamin Harich, Léo Guignard, Stephan Preibisch, Spencer Shorte, Philipp J Keller, Pavel Tomancak, Anastasios Pavlopoulos   +10 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq [PDF]

, 2016
Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq Kwok Yeung Tsang1, Xiangyu Li2, Jin Gu2, Danny Chan1, Michael Q. Zhang2,3, Kathryn SE Cheah1 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of ...
Tsang, KY, Gu, J, Li, X, Chan, D, Zhang, MQ, Cheah, KSE   +5 more
core  

The species specific effects of Mesenchymal stem cell conditioned medium on proliferating mouse and rat adult neural stem, progenitor cells [PDF]

, 2012
Adult stem cells reside in different tissues and organs of the adult organism. Among these cells are Mesenchymal stem cells (MSCs) and neural stem and progenitor cells (NSPCs).
Dechant, Franz - Xaver
core   +1 more source

Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

eLife, 2017
Reconstructing the lineage of cells is central to understanding how the wide diversity of cell types develops. Here, we provide the neurosensory lineage reconstruction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo over ...
Sylvia Dyballa, Thierry Savy, Philipp Germann, Karol Mikula, Mariana Remesikova, Róbert Špir, Andrea Zecca, Nadine Peyriéras, Cristina Pujades   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Influence of the MAPK Pathway on T Cell Lineage Commitment [PDF]

, 1997
During development, progenitor thymocytes differentiate into either CD4 or CD8 T cells, and this fate decision depends on the specificity of the T cell antigen receptor (TCR) for MHC class II or class I molecules.
Sharp, Leslie L, Schwarz, David A, Cynthia M Bott, Bott, Cynthia M, Marshall, Christopher J, Hedrick, Stephen M, Leslie L Sharp, David A Schwarz, Stephen M Hedrick, Christopher J Marshall   +9 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies

Nanomaterials
Multiplexed biosensing methods for simultaneously detecting multiple biomolecules are important for investigating biological mechanisms associated with physiological processes, developing applications in life sciences, and conducting medical tests.
Shangjie Zou, Guangdun Peng, Zhiqiang Ma
doaj   +1 more source