Results 111 to 120 of about 5,421,188 (313)
eLife, 2019 The insect central complex (CX) is a conserved brain region containing 60 + neuronal subtypes, several of which contribute to navigation. It is not known how CX neuronal diversity is generated or how developmental origin of subtypes relates to function ...
Luis F Sullivan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
İstanbul Medical Journal, 2018 Introduction: Human induced pluripotent stem cells (hiPSCs) have been recognized as key progenitor cells for liver regeneration, which could potentially be used in the repair of liver injury.
Nasim Parsafam +6 more
doaj +1 more source
eLife, 2018 During development, coordinated cell behaviors orchestrate tissue and organ morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful framework to elucidate the mechanisms of morphogenesis. To study the cellular basis of limb
Carsten Wolff +10 more
doaj +1 more source
Cell Lineage Determination in the Mouse.
Cell Structure and Function, 2001 During the peri-implantation development of the mouse embryo from the blastocyst through gastrulation, Pou5f1 (OCT-4) down-regulation is closely linked to the initial step of lineage allocation to extraembryonic and embryonic somatic tissues. Subsequently, differentiation of the lineage precursors is subject to inductive tissue interactions and ...
M. Watson, Catherine, P.L. Tam, Patrick
openaire +3 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
A gene regulatory network for cell differentiation in Caenorhabditis elegans
, 2003 Biological development is a remarkably complex process. A single cell, in an appropriate environment, contains enough information to produce a wide variety of specialised cell types, whose spatial and temporal dynamics interact to form intricately ...
Geard, N L, Wiles, J
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Lineage-specific S-cell extinction time determines linage size.
(Shaded areas show the range between the 2.5% and 97.5% quantile across 5 billion simulations). (A) Lineage-specific growth trajectories under the SAN model stratified by the lineage’s S-cell extinction time TS.
Arndt von Haeseler (8213) +5 more
core +1 more source
Injury activates transient olfactory stem cell states with diverse lineage capacities [PDF]
, 2017 Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques,
Sanchez, Michael A +27 more
core +1 more source