Results 111 to 120 of about 12,335,534 (353)

Enhanced substrate stress relaxation promotes filopodia-mediated cell migration

Nature Materials, 2021
Kolade Adebowale, Ze Gong, Jay Hou, Katrina M. Wisdom, Damien Garbett, Hong-pyo Lee, Sungmin Nam, T. Meyer, D. Odde, V. Shenoy, Ovijit Chaudhuri   +10 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dsg2 ectodomain organization increases throughout desmosome assembly

Cell Adhesion & Migration
Desmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F. Dean, Rose M. Albert, Tomasz J. Nawara, Melanie Ubil, Reena R. Beggs, Alexa L. Mattheyses   +5 more
doaj   +1 more source

N-Glycosylation Induces the CTHRC1 Protein and Drives Oral Cancer Cell Migration [PDF]

, 2013
Gangli Liu, Pritam K. Sengupta, Basem T. Jamal, Hsiao-Ying Yang, Meghan P. Bouchie, Volkhard Lindner, Xaralabos Varelas, Maria A. Kukuruzinska   +7 more
openalex   +1 more source

BML-111, the agonist of lipoxin A4, suppresses epithelial-mesenchymal transition and migration of MCF-7 cells via regulating the lipoxygenase pathway

, 2023
Fen Xu, Xiaoyan Zhou, Lan Lin, Jing Xu, Yu Feng, Yuanqiao He, Hua Hao   +6 more
openalex   +1 more source

Regulation of ATP utilization during metastatic cell migration by collagen architecture

Molecular Biology of the Cell, 2018
Cells expend energy to migrate. Metastatic cancer cell energy levels were investigated as a function of collagen architecture. In more migration-permissive environments or when migration is pharmacologically inhibited, cells reduce ATP:ADP levels ...
Matthew R. Zanotelli, Zachary E. Goldblatt, Joseph P. Miller, François Bordeleau, Jiahe Li, Jacob A. VanderBurgh, Marsha C. Lampi, M. King, Cynthia A. Reinhart-King   +8 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Fe3O4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Cell Adhesion & Migration
This research aims to study the effect of magnetic nanoparticles of Fe3O4 (MNP Fe3O4) containing gambogic acid (GA-MNP Fe3O4) on colorectal cancer (CRC).
Xiaodong Fan, Chunyang Lv, Meiling Xue, Peng Meng, Xiaoping Qian   +4 more
doaj   +1 more source

BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma [PDF]

, 2019
Ye Yuan, Jingyi Jiang, Jia‐Mei Wang, Jia Sun, Chao Li, Bao‐Qin Liu, Jing Yan, Xiaona Meng, Hua‐Qin Wang   +8 more
openalex   +1 more source