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Cell migration at a glance [PDF]
Cell migration is a fundamental process, from simple, uni-cellular organisms such as amoeba, to complex multi-cellular organisms such as mammals. Whereas its main functions comprise mating and the search for food in simple organisms ([Manahan et al., 2004][1]), complexity brings a requirement ...
Miguel, Vicente-Manzanares +2 more
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An end-to-end software solution for the analysis of high-throughput single-cell migration data [PDF]
The systematic study of single-cell migration requires the availability of software for assisting data inspection, quality control and analysis. This is especially important for high-throughput experiments, where multiple biological conditions are tested
Ampe, Christophe +5 more
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Imaging of cell migration [PDF]
Cell migration is an essential process during many phases of development and adult life. Cells can either migrate as individuals or move in the context of tissues. Movement is controlled by internal and external signals, which activate complex signal transduction cascades resulting in highly dynamic and localised remodelling of the cytoskeleton, cell ...
Dirk, Dormann, Cornelis J, Weijer
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Sirt1 and cell migration [PDF]
Sirt1 is a type III histone deacetylase implicated in a wide range of physiological and pathophysiological roles. Acting though a myriad of non-histone substrates, Sirt1 modulates transcriptional regulation of energy metabolism and stress response, with important consequences on cell survival and a myriad of human pathologies.
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Mechanoreciprocity in cell migration [PDF]
Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here
Sjoerd van Helvert +2 more
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Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
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Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst
The pluripotent epiblast (EPI) is the founder tissue of almost all somatic cells. EPI and primitive endoderm (PrE) progenitors arise from the inner cell mass (ICM) of the blastocyst-stage embryo. The EPI lineage is distinctly identified by its expression
Panagiotis Xenopoulos +4 more
doaj +1 more source
Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]
Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry +4 more
core +1 more source
Actin protrusion dynamics plays an important role in the regulation of three-dimensional (3D) cell migration. Cells form protrusions that adhere to the surrounding extracellular matrix (ECM), mechanically probe the ECM and contract in order to displace ...
Tommy Heck +5 more
doaj +1 more source
The preceding studies have established the following points: Intrathymic labeling of thymic lymphocytes provides an adequate marker system to detect the migration of thymus cells to peripheral lymphoid sites. In the newborn, this comprises a major portion of the total lymphocyte population in lymph nodes and spleen.
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