Results 11 to 20 of about 953,028 (268)
Dimensions in cell migration [PDF]
Current Opinion in Cell Biology, 2013 The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the ...
Doyle, Andrew D +3 more
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Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187
Cell Death and Disease, 2022 The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1).
Xin Li +13 more
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Blood Advances, 2017 : CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive.
Dina B. AbuSamra +8 more
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Integrins in Cell Migration [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as ...
Anna, Huttenlocher, Alan Rick, Horwitz
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Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
eLife, 2015 The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood.
Batiste Boëda +1 more
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Tetraspanins in Cell Migration [PDF]
Cell Adhesion & Migration, 2015 Tetraspanins are a superfamily of small transmembrane proteins that are expressed in almost all eukaryotic cells. Through interacting with one another and with other membrane and intracellular proteins, tetraspanins regulate a wide range of proteins such as integrins, cell surface receptors, and signaling molecules, and thereby engage in diverse ...
Xupin, Jiang +2 more
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Cells, 2019 Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and the third cause of cancer-related mortality. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, which often results in liver fibrosis, cirrhosis, and ...
Liat Ninio +11 more
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Aquaporins and cell migration [PDF]
Pflügers Archiv - European Journal of Physiology, 2007 Aquaporin (AQP) water channels are expressed primarily in cell plasma membranes. In this paper, we review recent evidence that AQPs facilitate cell migration. AQP-dependent cell migration has been found in a variety of cell types in vitro and in mice in vivo. AQP1 deletion reduces endothelial cell migration, limiting tumor angiogenesis and growth. AQP4
M C, Papadopoulos +2 more
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BMC Cancer, 2018 Background Metastasis is a complex process which is difficult to study and model. Experimental ingenuity is therefore essential when seeking to elucidate the biological mechanisms involved.
Shirley Jean Keeton +4 more
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Cell migration at a glance [PDF]
Journal of Cell Science, 2005 Cell migration is a fundamental process, from simple, uni-cellular organisms such as amoeba, to complex multi-cellular organisms such as mammals. Whereas its main functions comprise mating and the search for food in simple organisms ([Manahan et al., 2004][1]), complexity brings a requirement ...
Miguel, Vicente-Manzanares +2 more
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