Results 41 to 50 of about 13,617,537 (304)

SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role

open access: yesCell Adhesion & Migration, 2020
To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (ΔSLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic ...
Yusuke Mizutani   +6 more
doaj   +1 more source

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β2-integrin activation and signaling

open access: yesCell Adhesion & Migration, 2023
MARCKS is an actin and PIP2-binding protein that plays an essential role in neutrophil migration and adhesion; however, the molecular details regarding MARCKS function in these processes remains unclear. Neutrophil adhesion and migration also require the
Haleigh Conley   +4 more
doaj   +1 more source

Actin dynamics in cell migration

open access: yesEssays in Biochemistry, 2019
Cell migration is an essential process, both in unicellular organisms such as amoeba and as individual or collective motility in highly developed multicellular organisms like mammals.
M. Schaks, Grégory Giannone, K. Rottner
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells

open access: yesCell Adhesion & Migration, 2020
DDR1 is a receptor tyrosine kinases for collagen and an adverse prognostic factor in primary and metastatic tumors.Despite this, DDR1 signaling and its functional consequences in tumor development remain unclear.
Irene Romayor   +2 more
doaj   +1 more source

Dimensions in cell migration [PDF]

open access: yesCurrent Opinion in Cell Biology, 2013
The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the ...
Doyle, Andrew D   +3 more
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Cell Migration Research Based on Organ-on-Chip-Related Approaches

open access: yesMicromachines, 2017
Microfluidic devices have been widely used for cell migration research over the last two decades, owing to their attractive features in cellular microenvironment control and quantitative single-cell migration analysis.
Xiaoou Ren, David Levin, Francis Lin
doaj   +1 more source

Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway

open access: yesCell Adhesion & Migration, 2020
A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors.
Joanna Pastwińska   +4 more
doaj   +1 more source

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

open access: yesNature, 2018
Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues.
E. Barriga   +3 more
semanticscholar   +1 more source

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