Results 81 to 90 of about 52,621 (199)

Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity.

, 2010
Chronic infectious diseases and cancers are often associated with suboptimal effector T cell responses. Enhancement of T cell costimulatory signals has been extensively studied for cancer immunotherapy but not so for the treatment of infectious disease ...
Hill, Geoffrey R, Sakaguchi, Shimon, Haque, Ashraful, Stanley, Amanda C., Stanley, Amanda C, Zhou, Yonghong, Kuns, Rachel D, Amante, Fiona H., Rivera, Fabian de Labastida, Yardley, Vanessa, Kuns, Rachel D., Engwerda, Christian R, de Labastida Rivera, Fabian, Engwerda, Christian R., Amante, Fiona H, Hill, Geoffrey R.   +15 more
core   +1 more source

Histochemistry and Cell Biology / Nucleolus and chromatin

, 2018
The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus organizer regions (NORs).
Schöfer, Christian, Weipoltshammer, Klara   +1 more
core   +1 more source

HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs

Nature Communications
Although best known as the site for ribosome assembly, the nucleolus organizes heterochromatin into transcriptionally repressed Nucleolus-Associated Domains (NADs).
Kartik Kulkarni, Gabriella Quinn, Jared Dela Rosa, Sean Goetsch, Vrushali Pandit, Lin Wang, Akane Sakaguchi, Sushama Sivakumar, Nikhil V. Munshi   +8 more
doaj   +1 more source

The Nucleolus

, 2016
The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures.
Hutten, S., A.I. Lamond, Lamond, A. I.; id_orcid, A. Nicolas, Ly, T., T. Ly, S. Hutten, Nicolas, A.   +7 more
core   +1 more source

The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies

, 2019
The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved in the biogenesis of ribosomes, essential macromolecular machines responsible for synthesizing all proteins required by the cell.
Jiri Bartek, Carl C. Correll, Miroslav Dundr, Correll, CC, Bartek, J,, Dundr, M   +5 more
core   +1 more source

Effects of Laser UV-Microirradiation (λ = 2573 A) on Proliferation of Chinese Hamster Cells [PDF]

, 1976
A laser uv-microbeam with a wavelength of 2573 Å having a minimum spot diameter of approx 0.5 μm was used to microirradiate interphase cells of a V-79 subline of Chinese hamster cells.
Cremer, Thomas, Schoeller, L., Cremer, Christoph, Zorn, Christian   +3 more
core  

Compositional reorganization of the nucleolus in budding yeast mitosis

, 2019
The nucleolus is a membraneless organelle of the nucleus and the site of rRNA synthesis, maturation, and assembly into preribosomal particles. The nucleolus, organized around arrays of rRNA genes (rDNA), dissolves during prophase of mitosis in metazoans,
Bloom, Kerry S., Girke, Philipp, Seufert, Wolfgang   +2 more
core   +1 more source

Circannual Cycle of the Sertoli Cell Nucleolus in Roe Deer, Capreolus capreolus, and Seasonal Changes of Its Leydig Cells: An Ultrastructural Study

Folia Veterinaria
Ruminant Sertoli cells, instead of a nucleolus with nucleolonema, have a vesicular nucleolus, first described as a multivesicular nuclear body (MNB). It consists of membrane vesicles and tubules covered with ribo-some-like granules. We studied the testes
Zibrín Martin, Holovská Katarína, Pivko Juraj   +2 more
doaj   +1 more source

A 23-Amino Acid Motif Spanning the Basic Domain Targets Zebrafish Myogenic Regulatory Factor Myf5 into Nucleolus

, 2009
Myf5 is a nuclear protein and one of the basic helix-loop-helix (bHLH) myogenic factors that play an important role in muscle specification and differentiation. The motif responsible for the nuclear translocation of Myf5 was unknown.
陳曜鴻; Chen, Yau-hung; Wang, Y. H.; Lu, C. H.; Tsai, H. J.
core   +1 more source

The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.

, 2013
Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their physiological relevance is well understood.
Mendiburo, M.J., Schwarz, H.J., Kremmer, E., Chlamydas, S., Heun, P., Padeken, J.   +5 more
core   +1 more source