Results 41 to 50 of about 61,707 (300)

Cell-penetrating peptide exploited syndecans

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010
Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas, Keller-Pinter, Aniko, Kusz, Erzsebet, Kolozsi, Csongor, Bozso, Zsolt, Toth, Gabor, Vizler, Csaba, Olah, Zoltan, Szilak, Laszlo   +8 more
openaire   +3 more sources

Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]

Exploration of Drug Science
Aim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda   +7 more
doaj   +1 more source

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte, 2021
Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall, Estelle Erkner, Jan Stichel, Annette G. Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T. Heiker   +6 more
doaj   +1 more source

Beyond the discovered peptides by Viktor Mutt – a contribution [PDF]

Proceedings of the Estonian Academy of Sciences
A summary of the results obtained in the collaboration between the laboratory of Prof. Viktor Mutt at Karolinska Institutet and our laboratory at Stockholm University, headed by Prof. Tamas Bartfai, is given.
Ülo Langel
doaj   +1 more source

New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]

, 2017
Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián, Argarañá, María Fernanda, de Zan, María Mercedes, Giorello, Antonella, Muller, Diana, Peña, Lucía Carolina, Prieto, Claudio, Veaute, Carolina Melania Isabel   +7 more
core   +1 more source

Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]

British Journal of Pharmacology, 2005
Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W., Christison, Richard, Bundell, Ken, Voyce, Catherine J., Brockbank, Sarah M V, Newham, Peter, Lindsay, Mark A.   +6 more
openaire   +2 more sources

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

Do Cell-Penetrating Peptides Actually “Penetrate” Cellular Membranes? [PDF]

Molecular Therapy, 2012
Cell-penetrating peptides (CPPs), also referred to as peptide transduction domains (PTDs), are polypeptide domains that can enter many, if not most, cell types. CPP/PTDs mediate transduction into cells of a wide range of cargos that otherwise lack bioavailability, such as peptides, proteins, antisense oligonucleotides, and small interfering RNAs.
Palm-Apergi, Caroline, Lönn, Peter, Dowdy, Steven F   +2 more
openaire   +2 more sources

Ligands for oral delivery of peptides across the blood-brain-barrier

Acta Materia Medica, 2022
Peptides are short chains of amino acids linked by peptide bonds. Many peptides and proteins are limited by their poor enzymatic stability and permeability across the intestinal epithelial membranes and/or blood-brain barrier (BBB).
Murad Al Gailani, Mengyang Liu, Jingyuan Wen   +2 more
doaj   +1 more source

Novel approaches in development of cell penetrating peptides

Journal of Applied Pharmaceutical Research, 2021
Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the
Vatsal R. Shah, Yamini D. Shah, Mansi N. Athalye   +2 more
doaj   +1 more source