Results 21 to 30 of about 5,562,033 (283)
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. [PDF]
PLoS ONE, 2015 Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins.
Bruno Ramos-Molina +7 more
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Nucleic acid delivery by cell-penetrating peptides [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Establishment of multiple novel mechanisms and applications of cell-penetrating peptides (CPP) has been demonstrated, leading to novel drug delivery systems.
Ülo Langel
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Glycosylated Cell‐Penetrating Peptides (GCPPs) [PDF]
ChemBioChem, 2019 AbstractThe cell membrane regulates the exchange of molecules and information with the external environment. However, this control barrier hinders the delivery of exogenous bioactive molecules that can be applied to correct cellular malfunctions. Therefore, the traffic of macromolecules across the cell membrane represents a great challenge for the ...
Iván Gallego +8 more
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Cell-penetrating peptides [PDF]
Plant Signaling & Behavior, 2008 Internalization of cell-penetrating peptides, well described in mammalian cell system, has recently been reported in a range of plant cells by three independent groups. Despite fundamental differences between animal cell and plant cell composition, the CPP uptake pattern between the mammalian system and the plant system is very similar. Tat, Tat-2 pVEC
François, Eudes, Archana, Chugh
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Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
JCI Insight, 2021 To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh +11 more
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Bioactive Materials, 2022 Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
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Adipocyte, 2021 Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall +6 more
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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]
Exploration of Drug ScienceAim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré +7 more
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Arginine‐rich cell‐penetrating peptides [PDF]
FEBS Letters, 2009 Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a
Schmidt, Nathan +3 more
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Mitochondrial Targeting Probes, Drug Conjugates, and Gene Therapeutics
, 2021 Mitochondria represent an important drug target for many phatology, including neurodegeneration, metabolic disease, heart failure, ischemia-reperfusion injury, and cancer.
Tove Kivijärvi +11 more
core +1 more source