Results 31 to 40 of about 993 (207)
Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]
British Journal of Pharmacology, 2005 Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W. +6 more
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Ligands for oral delivery of peptides across the blood-brain-barrier
Acta Materia Medica, 2022 Peptides are short chains of amino acids linked by peptide bonds. Many peptides and proteins are limited by their poor enzymatic stability and permeability across the intestinal epithelial membranes and/or blood-brain barrier (BBB).
Murad Al Gailani +2 more
doaj +1 more source
Cell-penetrating peptide exploited syndecans
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010 Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas +8 more
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Cell-penetrating peptides transport therapeutics into cells [PDF]
Pharmacology & Therapeutics, 2015 Nearly 30years ago, certain small, relatively nontoxic peptides were discovered to be capable of traversing the cell membrane. These cell-penetrating peptides, as they are now called, have been shown to not only be capable of crossing the cell membrane themselves but can also carry many different therapeutic agents into cells, including small molecules,
Joshua D, Ramsey, Nicholas H, Flynn
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Novel approaches in development of cell penetrating peptides
Journal of Applied Pharmaceutical Research, 2021 Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the
Vatsal R. Shah +2 more
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A brief introduction to cell‐penetrating peptides [PDF]
Journal of Molecular Recognition, 2003 AbstractCell membranes act as protective walls to exclude most molecules that are not actively imported by living cells. This is an efficient way for a cell to prevent uncontrolled influx or efflux of solutes, which otherwise would be harmful to it.
Pontus, Lundberg, Ulo, Langel
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Communications Biology, 2023 Using a fluorescence complementation assay, Delivered Complementation in Planta (DCIP), we demonstrate cell-penetrating peptide-mediated cytosolic delivery of peptides and recombinant proteins in Nicotiana benthamiana.
Jeffrey W. Wang +7 more
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Effective Design of Multifunctional Peptides by Combining Compatible Functions.
PLoS Computational Biology, 2016 Multifunctionality is a common trait of many natural proteins and peptides, yet the rules to generate such multifunctionality remain unclear. We propose that the rules defining some protein/peptide functions are compatible. To explore this hypothesis, we
Christian Diener +6 more
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Optimization of the cyclotide framework to improve cell penetration properties
Frontiers in Pharmacology, 2015 Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their ...
Yen-Hua eHuang +4 more
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Properties of cell penetrating peptides (CPPs) [PDF]
IUBMB Life, 2006 Different approaches have been developed for the introduction of macromolecules, proteins and DNA into target cells. Viral (retroviruses, lentiviruses, etc.) and nonviral (liposomes, bioballistics etc.) vectors as well as lipid particles have been tested as DNA delivery systems.
Alexandre, Kerkis +3 more
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