Results 31 to 40 of about 201,264 (309)
Cell Polarity: Getting the PARty Started [PDF]
Current Biology, 2019 Polarity establishment is a key developmental process, but what determines its timing is poorly understood. New research in Caenorhabditis elegans demonstrates that the PAR polarity system extensively reconfigures before becoming competent to polarize. By inhibiting membrane localization of anterior PAR proteins, AIR-1 (aurora A) and PLK-1 (polo kinase)
Boxem, Mike, van den Heuvel, Sander
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Cell Polarity: The importance of being polar [PDF]
Current Biology, 1995 Cell polarization is often accompanied by cytoskeletal rearrangements. Two signalling proteins, a GTPase and a kinase, are required for both actin and microtubule rearrangements. Are these two systems coupled?
Glotzer, Michael, Hyman, Anthony A.
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TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics
eLife, 2016 Segmentation and tracking of cells in long-term time-lapse experiments has emerged as a powerful method to understand how tissue shape changes emerge from the complex choreography of constituent cells.
Raphaël Etournay +8 more
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Cell Polarity: Centrosomes Release Signals for Polarization [PDF]
Current Biology, 2012 New findings reveal that, in Caenorhabditis elegans embryos, the centrosome provides signals that induce cell polarization, independently of its function as the microtubule-organizing center.
Sumiyoshi, Eisuke, Sugimoto, Asako
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Advanced Science, 2021 Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disease.
Fabienne Lamballe +16 more
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, 2023 Immune cells are responsible for pathogen detection and elimination, as well as for signaling to other cells the presence of potential danger. In order to mount an efficient immune response, they need to move and search for a pathogen, interact with other cells, and diversify the population by asymmetric cell division.
Pineau, Judith +3 more
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Cell polarity: Par for the polar course [PDF]
Current Biology, 1997 The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.
Nelson, W.James, Grindstaff, Kent K.
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Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity [PDF]
Developmental Cell, 2011 Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic ...
Gray, Ryan S. +2 more
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Mechanobiology of the nucleus during the G2-M transition
NucleusCellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events.
Joana T. Lima, Jorge G. Ferreira
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Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome
Nature Communications, 2020 While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations.
Mengnan Li +21 more
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