Results 41 to 50 of about 201,264 (309)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. [PDF]

PLoS Biology, 2013
The spatiotemporal control of cell polarity is crucial for the development of multicellular organisms and for reliable polarity switches during cell cycle progression in unicellular systems.
Franz Meitinger, Heidi Richter, Sabrina Heisel, Birgit Hub, Wolfgang Seufert, Gislene Pereira   +5 more
doaj   +1 more source

Combined effect of cell geometry and polarity domains determines the orientation of unequal division

eLife, 2021
Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis.
Benoit G Godard, Remi Dumollard, Carl-Philipp Heisenberg, Alex McDougall   +3 more
doaj   +1 more source

Polarized Cells, Polarized Views: Asymmetric Cell Division in Hematopoietic Cells [PDF]

Frontiers in Immunology, 2014
It has long been recognized that alterations in cell shape and polarity play important roles in coordinating lymphocyte functions. In the last decade, a new aspect of lymphocyte polarity has attracted much attention, termed asymmetric cell division (ACD).
Kim ePham, Kim ePham, Faruk eSacirbegovic, Faruk eSacirbegovic, Sarah M Russell, Sarah M Russell, Sarah M Russell   +6 more
openaire   +4 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Unified quantitative characterization of epithelial tissue development

eLife, 2015
Understanding the mechanisms regulating development requires a quantitative characterization of cell divisions, rearrangements, cell size and shape changes, and apoptoses.
Boris Guirao, Stéphane U Rigaud, Floris Bosveld, Anaïs Bailles, Jesús López-Gay, Shuji Ishihara, Kaoru Sugimura, François Graner, Yohanns Bellaïche   +8 more
doaj   +1 more source

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? [PDF]

Open Biology, 2013
Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial for ...
Anna Noatynska, Nicolas Tavernier, Monica Gotta, Lionel Pintard   +3 more
doaj   +1 more source

Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.

PLoS Computational Biology, 2021
Epithelial tissues form folded structures during embryonic development and organogenesis. Whereas substantial efforts have been devoted to identifying mechanical and biochemical mechanisms that induce folding, whether and how their interplay ...
Fu-Lai Wen, Chun Wai Kwan, Yu-Chiun Wang, Tatsuo Shibata   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Cell Polarity Signaling: Focus on Polar Auxin Transport [PDF]

Molecular Plant, 2008
Polar auxin transport, which is required for the formation of auxin gradients and directional auxin flows that are critical for plant pattern formation, morphogenesis, and directional growth response to vectorial cues, is mediated by polarized sub-cellular distribution of PIN-FORMED Proteins (PINs, auxin efflux carriers), AUX1/AUX1-like proteins (auxin
Gao, Xiaowei, Nagawa, Shingo, Wang, Genxuan, Yang, Zhenbiao   +3 more
openaire   +2 more sources