Results 31 to 40 of about 13,797,858 (403)

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

Cells, 2020
The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus, Montserrat Marí, José T. Ortiz-Pérez, Gerry A. F. Nicolaes, Albert Morales, Pablo García de Frutos   +5 more
doaj   +1 more source

Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro [PDF]

, 2002
The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological ...
B. L HAZLEMAN, Brandt KD, Day RO, Dingle JT, Dingle JT, Flint M, G. P. RILEY, Gelberman RH, Hugenberg ST, M. COX, Martel-Pelletier J, Pelletier J-P, R. L. HARRALL, Rolf C, S. CLEMENTS, Scott JE, Thomas J   +16 more
core   +1 more source

Migration and proliferation dichotomy in tumor cell invasion [PDF]

, 2006
We propose a two-component reaction-transport model for the migration-proliferation dichotomy in the spreading of tumor cells. By using a continuous time random walk (CTRW) we formulate a system of the balance equations for the cancer cells of two ...
A. Iomin, Alexander Iomin, E. W. Montroll, J. D. Murray, M. Freidlin, Sergei Fedotov   +5 more
core   +1 more source

Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation

Frontiers in Endocrinology, 2019
Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited number of germ cells, the final number of Sertoli cells reached ...
S. Meroni, M. Galardo, G. Rindone, A. Gorga, M. Riera, S. Cigorraga   +5 more
semanticscholar   +1 more source

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

Oncogenesis, 2017
Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent signaling processes.
Z. Fan, A. Wirth, D. Chen, C. Wruck, M. Rauh, M. Buchfelder, N. Savaskan   +6 more
semanticscholar   +1 more source

Cancer metabolism at a glance [PDF]

, 2016
A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal, Kamphorst, Jurre J., Markert, Elke K., Schug, Zachary T., Tardito, Saverio, Vazquez, Alexei   +5 more
core   +2 more sources

Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Nature Communications, 2017
Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly ...
Ning Huang, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao, Runsheng He, Junlin Teng, Jianguo Chen   +7 more
doaj   +1 more source

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. [PDF]

, 2017
Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
A Ootani, A Ralston, A Roostaee, AG Muntean, Aimee Flores, B Ohlstein, B-Z Chen, C Moolenbeek, C Stringari, C Yang, CA Micchelli, CA Micchelli, Carl S. Thummel, CCP Aires, Christian S. Earl, Claire Bensard, D Dutta, D Karolchik, Dean Y. Li, DK Bricker, Don Delker, Dona R. Wisidagama, E Berger, F Cao, H Jiang, H Li, H Li, H Tateno, Heather R. Christofk, Helong Zhao, I Martínez-Reyes, J Benavides, J Wang, J Wang, James E. Cox, Jared Rutter, Jason Tanner, JC Schell, Jeffrey Mohlman, JL Golob, John C. Schell, JS Wu, K Birsoy, K Ito, K Nishino, K Weber, Kristofor A. Olson, KT Pate, KW McCool, LB Sullivan, Lei Jiang, Lise K. Sorensen, LK Boroughs, LR Edmunds, LR Gray, M Uhlen, M Uhlen, MA Keller, Mary P. Bronner, MB Gerstein, MJ Dailey, MJ Rodríguez-Colman, N Barker, N Buchon, NM Vacanti, O Warburg, PA Vigueira, Peng Wei, Priyanka Kanth, R Camarda, Ralph J. DeBerardinis, RB Flavell, Ren Miao, RW Daniels, S Beyaz, S Herzig, S Simmini, T Bender, T Sato, T Sato, T Sato, T Simsek, T. Cameron Waller, William E. Lowry, X Yin, X-M Wang, Y-Y Fan   +86 more
core   +1 more source

Cell proliferation: concluding remarks

Environmental Health Perspectives, 1993
In beginning this overview, I want to acknowledge the fact that, even though I disagree with most of his conclusions, Bruce Ames has played an important role in further stimulating interest in cell proliferation in carcinogenesis. This meeting has provided a balanced discussion of the current state of knowledge in this Eleld.
openaire   +2 more sources

circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma

Cell Death and Disease, 2018
Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells.
Gen-wen Chen, Yanting Shi, Mengmeng Liu, Jianyong Sun   +3 more
semanticscholar   +1 more source