Results 81 to 90 of about 5,248,930 (285)

Evaluating cell growth and hypoxic regions of 3D spheroids via a machine learning approach

Machine Learning: Science and Technology
This study investigated the applicability of the area of spheroids and hypoxic regions for efficient evaluation of drug efficacy using machine learning (ML).
Jaekak Yoo, Jae Won Choi, Eunha Kim, Eun-Jung Park, Ahruem Baek, Jaeseok Kim, Mun Seok Jeong, Youngwoo Cho, Tae Geol Lee, Min Beom Heo   +9 more
doaj   +1 more source

Cell size regulation in bacteria [PDF]

Physical Review Letters, 2014
Various bacteria such as the canonical gram negative Escherichia coli or the well-studied gram positive Bacillus subtilis divide symmetrically after they approximately double their volume. Their size at division is not constant, but is typically distributed over a narrow range. Here, we propose an analytically tractable model for cell size control, and
openaire   +5 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Defining the dimensions of circulating tumor cells in a large series of breast, prostate, colon, and bladder cancer patients

Molecular Oncology, 2021
Circulating tumor cells (CTCs) in the blood of cancer patients are of high clinical relevance. Since detection and isolation of CTCs often rely on cell dimensions, knowledge of their size is key.
Pauline A. J. Mendelaar, Jaco Kraan, Mai Van, Leonie L. Zeune, Leon W. M. M. Terstappen, Esther Oomen‐de Hoop, John W. M. Martens, Stefan Sleijfer   +7 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Adaptive abilities of benthic microalga Attheya ussurensis to prolonged contamination with a salt of hexavalent chromium in culture

Известия ТИНРО, 2014
Adaptive capacity of benthic microalga Attheya ussurensis (Bacillariophyta) from Peter the Great Bay, Japan Sea to the medium contamination with a salt of hexavalent chromium is tested in laboratory culture.
Nina A. Aizdaicher, Olga B. Gostyukhina
doaj   +1 more source

A Cell Size Theory of Aging [PDF]

Developmental Cell, 2018
The factors determining longevity of different animals are incompletely defined. In this issue of Developmental Cell, Anzi et al. (2018) show that distinct strategies for postnatal pancreatic growth operate in different mammals and correlate with lifespan, with short-lived species exhibiting increasing pancreatic cell size and long-lived animals ...
Krushna C. Patra, Nabeel Bardeesy
openaire   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

eLife, 2018
Animal cells within a tissue typically display a striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown.
Shixuan Liu, Miriam Bracha Ginzberg, Nish Patel, Marc Hild, Bosco Leung, Zhengda Li, Yen-Chi Chen, Nancy Chang, Yuan Wang, Ceryl Tan, Shulamit Diena, William Trimble, Larry Wasserman, Jeremy L Jenkins, Marc W Kirschner, Ran Kafri   +15 more
doaj   +1 more source