Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease
Frontiers in Physiology, 2022 The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import in the ER during translation.
Jan B. Parys +2 more
doaj +1 more source
Cell Survival Signaling in Neuroblastoma [PDF]
Anti-Cancer Agents in Medicinal Chemistry, 2013 Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal cellular senescence or apoptosis.
Elizabeth A. Beierle +2 more
openaire +3 more sources
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
Science Signaling, 2019 AMPK ensures cell survival during energetic stress by stimulating the kinase Akt through mTORC2. Surviving energetic stress with mTORC2 The roles and regulation of mTORC2, a multiprotein complex that contains the kinase mTOR in association with rictor ...
D. Kazyken +16 more
semanticscholar +1 more source
Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. [PDF]
, 2010 The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival.
Daniels, TR +5 more
core +1 more source
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
Cell Reports, 2015 The mTORC1 complex is central to the cellular response to changes in nutrient availability. The signaling adaptor p62 contributes to mTORC1 activation in response to amino acids and interacts with TRAF6, which is required for the translocation of mTORC1 ...
Juan F. Linares +6 more
doaj +1 more source
CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells
Frontiers in Molecular Neuroscience, 2017 Neuroblastoma is the most common solid extra cranial tumor in infants. Improving the clinical outcome of children with aggressive tumors undergoing one of the multiple treatment options has been a major concern.
Namrata Chaudhari +3 more
doaj +1 more source
2D mapping of radiation dose and clonogenic survival for accurate assessment of in vitro X-ray GRID irradiation effects [PDF]
, 2022 Spatially fractionated radiation therapy (SFRT or GRID) is an approach to deliver high local radiation doses in an 'on-off' pattern. To better appraise the radiobiological effects from GRID, a framework to link local radiation dose to clonogenic survival needs to be developed. A549 (lung) cancer cells were irradiated in T25 cm$^2$ flasks using 220 kV X-
arxiv +1 more source
Cancer cells survive with survivin [PDF]
Cancer Science, 2008 Survivin has multiple functions including cytoprotection, inhibition of cell death, and cell‐cycle regulation, especially at the mitotic process stage, all of which favor cancer survival. Many studies on clinical specimens have shown that survivin expression is invariably up‐regulated in human cancers and is associated with resistance to chemotherapy ...
Hirofumi Yamamoto +2 more
openaire +2 more sources
3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival [PDF]
, 2011 Copyright © 2011 Association for Research in Vision and Ophthalmology. This article is available open access through the publisher’s website at the link below.Purpose.
Fu, Hongmei +4 more
core +2 more sources
Isolation and Characterization of Crab Haemolymph Exosomes and Its Effects on Breast Cancer Cells (4T1) [PDF]
Cell Journal, 2021 Objective: The use of animal or plant exosomes in cancer treatment is promising because of their easy access and low cost. Freshwater crabs are used in traditional Iranian medicine to treat cancer.
Leila Rezakhani +4 more
doaj +1 more source