Results 1 to 10 of about 1,789,995 (350)

HPV-18-Immortalised Cells Require the Downregulation of the SncmtRNA-2/Hsa-miR-620 Axis During Cell Transformation [PDF]

Medicina
Background and Objectives: Non-coding RNAs (ncRNAs) are genetic transcripts that do not produce proteins but are increasingly recognised for their roles in cellular processes and disease. Specifically, ncRNAs are implicated in the landscape activation of
Emanuel Jeldes, Manuel Varas-Godoy, Paulina González-Chacón, América V. Campos, Alberto J. M. Martín, Camilo Villaman, Ángel Roco-Videla, Jaime Villegas Olavarría, Claudio Villota Arcos   +8 more
doaj   +2 more sources

Oncotransformation in Bhas 42 Cell Transformation Assay by Typical Non-Genotoxic Carcinogens, PFOA and PFOS, and Time-Course Transcriptome Analysis [PDF]

Biomolecules
Perfluorinated alkyl substances and polyfluorinated alkyl substances (PFASs) are long-chain compounds, with perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) being the most well-known examples.
Kiyomi Ohmori
doaj   +2 more sources

Dendrosomal nanocurcumin prevents EBV-associated cell transformation by targeting the lytic cycle genes of the Epstein-Barr virus in the generation of lymphoblastoid cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Targeting the lytic cycle of the Epstein-Barr virus (EBV) has been considered a new treatment strategy for malignancies caused by this virus.
Mahboobeh Cheragh, Majid Sadeghizadeh, Mohammad Hasan Pouriayevali, Masoud Parsania   +3 more
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Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling. [PDF]

Clin Cancer Res
El Zarif T, Meador CB, Qiu X, Seo JH, Davidsohn MP, Savignano H, Lakshminarayanan G, McClure HM, Canniff J, Fortunato B, Li R, Banwait MK, Semaan K, Eid M, Long H, Hung YP, Mahadevan NR, Barbie DA, Oser MG, Piotrowska Z, Choueiri TK, Baca SC, Hata AN, Freedman ML, Berchuck JE.   +24 more
europepmc   +3 more sources

Diffuse osteolytic lesions in leukemic transformation of myelofibrosis [PDF]

Archive of Oncology, 2007
Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of reticulin and collagen in the bone marrow, extramedullary hematopoiesis, dacryocytosis and leukoerythroblastic blood smear.
Jurišić Vladimir, Čolović Nataša, Pavlović Sonja, Čolović Milica   +3 more
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New Sesquiterpene Glycosides from the Flowers of Aster koraiensis and Their Inhibition Activities on EGF- and TPA-Induced Cell Transformation

Plants, 2023
In total, four new eudesmane-type sesquiterpene glycosides, askoseosides A–D (1–4), and 18 known compounds (5–22) were isolated from the flowers of Aster koraiensis via chromatographic techniques.
Young-Hye Seo, Ji-Young Kim, Seung-Mok Ryu, Sun-Young Hwang, Mee-Hyun Lee, Nahyun Kim, Hojun Son, A-Yeong Lee, Hyo-Seon Kim, Byeong-Cheol Moon, Dae-Sik Jang, Jun Lee   +11 more
doaj   +1 more source

Novel Therapeutic Approaches for KRAS-Mutated Lung Cancer Involving LZTR1 Genetic Alteration

Medical Sciences Forum, 2023
A total of 30% of lung adenocarcinoma are driven by activating KRAS mutations. The treatment options for KRAS-mutant lung cancer are still limited as a challenge for therapy is the high heterogeneity within KRAS mutant tumors.
Raj N. Sewduth, Tonci Ivanisevic, Peihua Zhao, Anna A. Sablina   +3 more
doaj   +1 more source

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

Frontiers in Oncology, 2021
The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal ...
Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider   +4 more
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Enhanced Biomass and Astaxanthin Production of Haematococcus pluvialis by a Cell Transformation Strategy with Optimized Initial Biomass Density

Marine Drugs, 2020
Astaxanthin from H. pluvialis is an antioxidant and presents a promising application in medicine for human health. The two-stage strategy has been widely adopted to produce astaxanthin by the Haematococcus industry and research community.
Feng Li, Minggang Cai, Mingwei Lin, Xianghu Huang, Jun Wang, Hongwei Ke, Chunhui Wang, Xuehong Zheng, Ding Chen, Shihui Yang   +9 more
doaj   +1 more source

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

eLife, 2023
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state.
Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel   +9 more
doaj   +1 more source