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Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Nature Communications, 2021
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero   +19 more
doaj   +2 more sources

Metabolic Plasticity of Tumor Cell Mitochondria [PDF]

Frontiers in Oncology, 2018
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell.
Giuseppe Cannino, Francesco Ciscato, Ionica Masgras, Carlos Sánchez-Martín, Andrea Rasola   +4 more
doaj   +3 more sources

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]

Frontiers in Cell and Developmental Biology
PurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat, Taylor Laframboise, Jessica Dougherty, Marc S. Mendonca, Douglas R. Boreham, Douglas R. Boreham, T. C. Tai, T. C. Tai, T. C. Tai, Christopher Thome, Christopher Thome, Christopher Thome, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam   +14 more
doaj   +2 more sources

Emerging roles of telomeric chromatin alterations in cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Stefano Cacchione, Annamaria Biroccio, Angela Rizzo   +2 more
doaj   +3 more sources

The Autoimmune Gastritis Puzzle: Emerging Cellular Crosstalk and Molecular Pathways Driving Parietal Cell Loss and ECL Cell Hyperplasia [PDF]

Cells
Autoimmune gastritis (AIG) is a chronic, organ-specific autoimmune disease characterized by progressive destruction of gastric parietal cells driven by autoreactive CD4+ T-cells, epithelial stress pathways, and microbial factors.
Sara Massironi, Elena Oriani, Giuseppe Dell’Anna, Silvio Danese, Federica Facciotti   +4 more
doaj   +2 more sources

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
A Bianchini, A Villanueva, Alexandra Junger, Antonia Rizzani, DA Altomare, EF Dunn, Enrico N. De Toni, Günter Schneider, HG Wendel, I Fabregat, I Nicoletti, IBCJ Rosenwald, JE Dancey, Jennifer Altomonte, JH Connor, JS Orlando, K Shinozaki, K Shinozaki, L Mishra, LM Schang, M Ahmed, M Hidalgo, M Ikeda, M Sun, Maciej Lesniak, N Kato, N Kato, N Kemeny, N Sonenberg, NA Hamid, Nobuyuki Kato, O Ebert, O Ebert, O Larsson, Oliver Ebert, P Chakraborty, P Newell, PC Chiang, PL Hallenbeck, RB Kjellerup, RL Silva, RM Memmott, Roland M. Schmid, S Balachandran, S Joshi, S Marozin, S Oliere, S Sei, S Sell, Sabrina Marozin, SM Steinberg, SR Kimball, T Cascone, T Nakamura, T Ueda, TL Nguyen, TP Cripe, WE Thasler, Wolfgang E. Thasler, XQ Lun, Y Ma   +60 more
core   +17 more sources

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +1 more source

Effects of Curcumin on Sodium Arsenite Induced Neoplastic Cell Transformation in Balb/c 3T3 Cells [PDF]

Brazilian Archives of Biology and Technology, 2021
HIGHLIGHTS Sodium arsenite can cause neoplastic transformation in cells. Curcumin reduced cell viability and increased LDH activity in transformed Balb/c 3T3 cells. Curcumin caused DNA damage in transformed Balb/c 3T3 cells.
Busra Demircioglu, Yasemin Aydin, Banu Orta-Yilmaz, Nebahat Yildizbayrak, Melike Erkan   +4 more
doaj   +1 more source

Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis

Cumhuriyet Dental Journal, 2021
Objective. To assess the clinical-pathological factors related to the malignant transformation of oral leukoplakia. Materials and Methods. A search for articles on malignant transformation factors related to oral leukoplakia was conducted in the ...
Cristina Fuentes-perez, Alberto Rodriguez-archilla   +1 more
doaj   +1 more source

Elastic Moduli of Cells undergoing Neoplastic Transformation [PDF]

Biophysical Journal, 2013
Using an Atomic Force Microscope (AFM) with a 5.3 um diameter spherical probe we determined the elastic modulus of human mammary epithelial cells (HMEC) as they undergo neoplastic transformation from normal to immortal, tumorigenic, and finally metastatic. We did the measurements over both cytoplasmic and nuclear regions; and as a function of the cells
Guo, Xinyi, Guthold, Martin, Bonin, Keith   +2 more
openaire   +2 more sources