Results 21 to 30 of about 593,168 (347)

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

Stem cell research & therapeutics, 2019
Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential ...
S. Melnik, Nadine Werth, S. Boeuf, E. Hahn, T. Gotterbarm, M. Anton, W. Richter   +6 more
semanticscholar   +1 more source

The role of E-cadherin in neoplastic evolution of epithelial cells

Успехи молекулярной онкологии, 2015
Interaction of the extracellular domains of the transmembrane proteins cadherins provides cell-cell adhesion. For many years epithelial E- cadherin was regarded as a tumor suppressor and was used as a prognostic marker in cancer.
N. A. Gloushankova, I. Yu. Zhitnyak, D. V. Ayollo, S. N. Rubtsova   +3 more
doaj   +1 more source

Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-induced Neoplastic Cell Transformation*

Journal of Biological Chemistry, 2010
RSK2 is a widely expressed serine/threonine kinase, and its activation enhances cell proliferation. Here, we report that ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation.
Kangdong Liu, Yong-Yeon Cho, K. Yao, Janos Nadas, Dong Joon Kim, E. Cho, Mee-Hyun Lee, A. Pugliese, Ji-shuai Zhang, A. Bode, Z. Dong, Z. Dong   +11 more
semanticscholar   +1 more source

Squamous cell carcinoma arising in ovarian mature cystic teratoma: report of three cases

Journal of Pathology of Nepal, 2012
Malignant transformation of mature cystic teratoma of the ovary is rare. A wide variety of malignant tumors may arise within benign mature cystic teratoma.
R Bashyal, MC Lee
doaj   +1 more source

Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia

Haematologica, 2021
Adult T-cell leukemia-lymphoma (ATL), is a highly malignant T-cell neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1), characterized by a poor prognosis.
Greta Forlani, Mariam Shallak, Alessandra Tedeschi, Ilaria Cavallari, Ambroise Marçais, Olivier Hermine, Roberto S. Accolla   +6 more
doaj   +1 more source

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? [PDF]

, 2018
Indexación: Scopus.Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for ...
Aggarwal, Akaike, Antonelli, Aoki, Balkwill, Balkwill, Balkwill, Ben-Baruch, Ben-Baruch, Ben-Baruch, Bentrem, Bikfalvi, Bressan, Carini, Caux, Cerutti, Chen, Chiovato, Clark, Evers, Fagin, Fallahi, Fallahi, Fallahi, Ferrannini, Fugazzola, Fulton, Giovannone, Harris, Haugen, Huang, Ichikawa, Ishikura, Keane, Keane, Khodarev, Kim, Lai, Lazebnik, Liao, Loetscher, Maggi, Mak, Mantovani, Mantovani, Marazuela, Marone, Matrisian, Matthys, McEvoy, Melillo, Melillo, Melillo, Melillo, Miccoli, Moser, Moser, Nagawa, Negri, Okayasu, Oppenheim, Pal, Pal, Pal, Paloyan, Paloyan, Peled, Peng, Pfaffl, Potlukova, Richmond, Richmond, Rizzoli, Rollins, Romagnani, Rothstein, Santoro, Serio, Serio, Shah, Shaha, Sonoo, Sorensen, Strieter, Strieter, Strieter, Sun, Taketo, Teixido, Toniolo, Tuttle, Vigneri, Ward, Ward, Ward, Welch, Wells, Wells, Wells, Wilhelm, Wu, Wynford-Thomas, Yang, Yeo, Zhang   +104 more
core   +1 more source

NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype

Cell Communication and Signaling, 2023
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and drives malignant transformation through ...
Amy Oh, M. Pardo, Anaelena Rodriguez, Connie Yu, Lisa Nguyen, Olin Liang, A. Chorzalska, P. M. Dubielecka   +7 more
semanticscholar   +1 more source

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia

EMBO Molecular Medicine, 2013
Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked.
Gonçalo Regalo, Achim Leutz
doaj   +1 more source

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

São Paulo Medical Journal, 2017
BACKGROUND: Malignant transformation of endometriosis in the abdominal wall is a rare and still poorly understood event. Less than 30 cases have been reported in the worldwide literature. Most cases of solid tumors are report in a previous abdominal scar
João Kleber de Almeida Gentile, Renato Migliore, Fábio Jorge Neubaner Kistenmacker, Marcio Menezes de Oliveira, Rodrigo Biscuola Garcia, Fang Chia Bin, Pedro Marcos Santinho Bueno de Souza, José César Assef   +7 more
doaj   +1 more source

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]

, 2020
According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel, Diaconu, Camelia Cristina, Greabu, Maria, Miricescu, Daniela, Rusu, Ioana Ruxandra, Spinu, Dan, Stanescu, Ana Maria Alexandra, Stefani, Constantin, Totan, Alexandra   +8 more
core   +3 more sources