Results 11 to 20 of about 13,969,136 (421)

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1978
The tridecamer d(A-A-T-G-G-T-A-A-A-A-T-G-G), which is complementary to 13 nucleotides of the 3'- and 5'-reiterated terminal sequences of Rous sarcoma virus 35S RNA, was added to chick embryo fibroblast tissue cultures infected with Rous sarcoma virus ...
Paul C. Zamecnik, Mary L. Stephenson
openalex   +2 more sources

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

eLife, 2019
Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis.
Karoliina Stefanius, Kelly Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs, Suneeta Chimalapati, Min S Kim, Venkat S Malladi, Rolf Brekken, Kim Orth   +9 more
doaj   +2 more sources

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Millions of people have been exposed to asbestos and are at increased risk of developing mesothelioma, an aggressive malignancy resistant to current therapies.
Jiaming Xue, S. Patergnani, C. Giorgi, Joelle S. Suarez, K. Goto, Angela Bononi, M. Tanji, F. Novelli, S. Pastorino, Ronghui Xu, N. Caroccia, A. Dogan, H. Pass, M. Tognon, P. Pinton, G. Gaudino, T. Mak, M. Carbone, Haining Yang   +18 more
semanticscholar   +1 more source

Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition

npj Precision Oncology, 2020
Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-driven
Jessica J. Lin, Adam Langenbucher, Pranav Gupta, S. Yoda, Isobel J. Fetter, M. Rooney, A. Do, M. Kem, Kylie Prutisto Chang, Audris Oh, E. Chin, D. Juric, R. Corcoran, I. Dagogo-Jack, J. Gainor, J. Stone, J. Lennerz, M. Lawrence, A. Hata, M. Mino‐Kenudson, A. Shaw   +20 more
semanticscholar   +1 more source

Small cell transformation of non-small cell lung cancer on immune checkpoint inhibitors: uncommon or under-recognized?

Journal for ImmunoTherapy of Cancer, 2020
Background Histological transformation of oncogene-driven lung adenocarcinoma to small cell lung cancer (SCLC) following treatment with tyrosine kinase inhibitors (TKIs) is a well-described phenomenon.
K. Sehgal, Andreas Varkaris, Hollis Viray, P. VanderLaan, Deepa Rangachari, D. Costa   +5 more
semanticscholar   +1 more source

T-Cell Transformation

Definitions, 2020
Morphologic alteration of small T lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins, mitogens such as phytohemagglutinins, and by specific antigens.

semanticscholar   +1 more source

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source

MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO₂NP and MWCNT

Nanomaterials, 2021
The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the ...
Sandra Ballesteros, Gerard Vales, Antonia Velázquez, Susana Pastor, Mohamed Alaraby, Ricard Marcos, Alba Hernández   +6 more
doaj   +1 more source

A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus [PDF]

, 1976
A quantitative Abelson murine leukemia virus (A-MuLV) lymphoid cell transformation assay has been developed using a semisolid agarose culture system. Under these conditions lymphoid cell transformation was shown to vary linearly with the dose of A-MuLV ...
Baltimore, David, Rosenberg, Naomi
core   +1 more source

Secondary Malignant Transformation of Giant Cell Tumor of Bone: Is It a Fate? [PDF]

Iranian Journal of Pathology, 2019
The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial
Sajjadeh Movahedinia, Tina Shooshtarizadeh, Hassan Mostafavi   +2 more
doaj   +1 more source