Results 31 to 40 of about 1,789,995 (350)

Establishment of human embryonic stem cell WAe009-A-74 carrying a Long QT syndrome mutation in KCNH2

Stem Cell Research, 2022
Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear.
Lixiang Sun, Jiaqi Zhong, Fujian Wu, Furong Li, Xiaofei Yang, Zhiyu Zeng   +5 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Fusion Protein-Collagen Scaffolds: A New Potential Therapy for Thin Endometrium

Fertility & Reproduction
Background: Thin endometrium (TE), a leading cause of uterine factor infertility, remains a clinical challenge with limited therapeutic options. This study evaluates the effect of intrauterine perfusion with fusion protein-collagen scaffolds (FP-CS ...
Xi Yan, Pengnan Hu
doaj   +1 more source

Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?

Frontiers in Bioengineering and Biotechnology, 2022
Exposure of the skin to an external stimulus may lead to a series of irreversible dysfunctions, such as skin aging, refractory wounds, and pigmented dermatosis.
Haiyan Wu, Haiyan Wu, Zhenchun Zhang, Zhenchun Zhang, Yuemeng Zhang, Zhenlin Zhao, Hongming Zhu, Hongming Zhu, Changwu Yue   +8 more
doaj   +1 more source

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]

, 2019
This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia, Frugis, Giovanna, Giannino, Donato, Iannelli, Maria Adelaide, Mauro, Maria Luisa, Mele, Giovanni, Nicolodi, Chiara, Paolis, Angelo De, Rugini, Eddo, Silvestri, Cristian, Sparvoli, Francesca, Testone, Giulio   +11 more
core   +1 more source

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]

, 2003
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio, Marinissen, Maria Julia, Offermanns, Stefan, Servitja, Joan-Marc, Simon, Melvin I.   +4 more
core   +1 more source

Overexpression of the Transcription Factor GROWTH-REGULATING FACTOR5 Improves Transformation of Dicot and Monocot Species

Frontiers in Plant Science, 2020
Successful regeneration of genetically modified plants from cell culture is highly dependent on the species, genotype, and tissue-type being targeted for transformation. Studies in some plant species have shown that when expression is altered, some genes
Jixiang Kong, Susana Martin-Ortigosa, John Finer, Nuananong Orchard, Andika Gunadi, Lou Ann Batts, Dhiraj Thakare, Bradford Rush, Oliver Schmitz, Maarten Stuiver, Paula Olhoft, David Pacheco-Villalobos   +11 more
doaj   +1 more source

The Regulation of Commodity Options [PDF]

, 1978
To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL ...
Berglund, Mattias, Collins, V. Peter, Dinets, Andrii, Ichimura, Koichi, Kwiecinska, Anna, Lagercrantz, Svetlana Bajalica, Larsson, Catharina, Porwit, Anna, Sulaiman, Luqman   +8 more
core   +3 more sources

Cell Dynamics Simulation of Kolmogorov-Johnson-Mehl-Avrami Kinetics of Phase Transformation

, 2005
In this study, we use the cell dynamics method to test the validity of the Kormogorov-Johnson-Mehl-Avrami (KJMA) theory of phase transformation. This cell dynamics method is similar to the well-known phase-field model, but it is a more simple and ...
Iwamatsu, Masao, Nakamura, Masato
core   +1 more source

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources