Results 31 to 40 of about 751,951 (166)

NUP98‐BPTF promotes oncogenic transformation through PIM1 upregulation

Cancer Medicine
Introduction Nucleoporin 98 (NUP98) fusion proteins are recurrently found in leukemia and are associated with unfavorable clinical outcomes. They are distributed to the nucleus and contribute to leukemogenesis via aberrant transcriptional regulation.
Mina Noura, Sakura Tomita, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +5 more
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BK Virus in Cancer Development

Current Issues in Pharmacy and Medical Sciences, 2018
Polyomavirus (PyV) was discovered by accident in 1950 in the course of describing an infectious factor causing multiple tumours in rodents. The term is derived from two Greek words: poly (many) and oma (tumour).
Pasternak Justyna, Kliszczewska Ewa, Polz-Dacewicz Malgorzata   +2 more
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Epicardial cell transformation

The FASEB Journal, 2010
The embryonic epicardium, which invests all the heart surface by midgestation, derives from an extracardiac progenitor tissue called the proepicardium. The embryonic epicardium gives rise to a population of mesenchymal cells called the epicardially‐derived cells (EPDCs) that populate the ...
openaire   +1 more source

Small cell transformation of non‐small cell lung cancer under immunotherapy: Case series and literature review

Thoracic Cancer, 2021
In advanced lung cancer treatment, immunotherapy provides durable responses in some patients. However, other patients experience progressive disease and the resistance mechanisms to immunotherapy have yet been fully elucidated.
Takuma Imakita, Kohei Fujita, Osamu Kanai, Misato Okamura, Masayuki Hashimoto, Koichi Nakatani, Satoru Sawai, Tadashi Mio   +7 more
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The role of the cytoskeleton in fibrotic diseases

Frontiers in Cell and Developmental Biology
Fibrosis is the process whereby cells at a damaged site are transformed into fibrotic tissue, comprising fibroblasts and an extracellular matrix rich in collagen and fibronectin, following damage to organs or tissues that exceeds their repair capacity ...
Caoyuan Niu, Yanan Hu, Kai Xu, Xiaoyue Pan, Lan Wang, Guoying Yu   +5 more
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Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an Amyotrophic Lateral Sclerosis Mouse Model

Cell Transplantation, 2013
Amyotrophic lateral sclerosis (ALS) is characterized by progressive dysfunction and degeneration of motor neurons in the central nervous system (CNS).
Chan-Il Choi, Young-Don Lee, Heejaung Kim, Seung Hyun Kim, Haeyoung Suh-Kim PhD, Sung-Soo Kim Ph.D.   +5 more
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Touching cells transform

The Journal of Cell Biology, 2001
![Graphic][1] Epithelial cell (top) meets fibroblast (bottom). Bonder/NAS The cytoskeleton of an epithelial cell is converted to a fibroblast-like morphology upon contact with a fibroblast.
openaire   +2 more sources

Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases

Respirology Case Reports, 2020
Pathological transformation to squamous cell carcinoma after epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor treatment has been reported, but details of the transformation remain unclear.
Hironori Uruga, Takeshi Fujii, Nobuyuki Nakamura, Shuhei Moriguchi, Kazuma Kishi, Hisashi Takaya   +5 more
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Rational treatment selection for primary Merkel Cell Carcinoma: a Rational MCC RCT comparing surgery and radiotherapy with parallel observational study

Efficacy and Mechanism Evaluation
Background Merkel cell carcinoma is a rare locally invasive skin cancer of older people. Standard management for primary Merkel cell carcinoma is surgery and/or radiotherapy, with no standard of care or unity of practice, based on retrospective ...
Neil M Steven, Sarah Pirrie, Yolande Jefferson-Hulme, Claire H Gaunt, Victoria Homer   +4 more
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Mechanism of Histologic Transformation of Drive Gene Positive Lung Adenocarcinoma in Targeted Therapy and Treatment Strategy

Chinese Journal of Lung Cancer, 2020
Patients with lung adenocarcinoma (ADC) who harbor drive gene mutation will inevitably develop drug resistance after receiving targeted therapy. The common mechanisms of drug resistance include secondary mutation of driver gene, change of non-driver gene,
Tongji XIE, Yan LI, Puyuan XING
doaj   +1 more source