Results 21 to 30 of about 28,363,573 (344)

Vision-dependent specification of cell types and function in the developing cortex.

Cell, 2022
The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is poorly understood at the level of cell types. We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA sequencing, visual deprivation ...
Sarah Cheng, Salwan Butrus, Liming Tan, Runzhe Xu, Srikant Sagireddy, J. Trachtenberg, K. Shekhar, S. Zipursky   +7 more
semanticscholar   +1 more source

Assembling animals: trees, genomes, cells, and contrast to plants

Frontiers in Ecology and Evolution, 2023
The Animal Kingdom is an astonishingly diverse group. Together with plants and fungi is one of the three major lineages of multicellular eukaryotes. Due to anthropocentrism and/or genuine scientific interest, their origin and diversification are pivotal ...
Jordi Paps, Maria Eleonora Rossi, Alexander M. C. Bowles, Marta Álvarez-Presas   +3 more
doaj   +1 more source

Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data

Nature Communications, 2022
Mapping cell types across a tissue is a central concern of spatial biology, but cell type abundance is difficult to extract from spatial gene expression data. We introduce SpatialDecon, an algorithm for quantifying cell populations defined by single cell
P. Danaher, Youngmi Kim, B. Nelson, Maddy Griswold, Zhi Yang, Erin Piazza, J. Beechem   +6 more
semanticscholar   +1 more source

Cornea organoids from human induced pluripotent stem cells. [PDF]

, 2017
The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M, Birk, David E, Chakravarti, Shukti, Foster, James W, Wahlin, Karl, Zack, Donald J   +5 more
core   +8 more sources

A connectome and analysis of the adult Drosophila central brain

eLife, 2020
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster.
Louis K Scheffer, C Shan Xu, Michal Januszewski, Zhiyuan Lu, Shin-ya Takemura, Kenneth J Hayworth, Gary B Huang, Kazunori Shinomiya, Jeremy Maitlin-Shepard, Stuart Berg, Jody Clements, Philip M Hubbard, William T Katz, Lowell Umayam, Ting Zhao, David Ackerman, Tim Blakely, John Bogovic, Tom Dolafi, Dagmar Kainmueller, Takashi Kawase, Khaled A Khairy, Laramie Leavitt, Peter H Li, Larry Lindsey, Nicole Neubarth, Donald J Olbris, Hideo Otsuna, Eric T Trautman, Masayoshi Ito, Alexander S Bates, Jens Goldammer, Tanya Wolff, Robert Svirskas, Philipp Schlegel, Erika Neace, Christopher J Knecht, Chelsea X Alvarado, Dennis A Bailey, Samantha Ballinger, Jolanta A Borycz, Brandon S Canino, Natasha Cheatham, Michael Cook, Marisa Dreher, Octave Duclos, Bryon Eubanks, Kelli Fairbanks, Samantha Finley, Nora Forknall, Audrey Francis, Gary Patrick Hopkins, Emily M Joyce, SungJin Kim, Nicole A Kirk, Julie Kovalyak, Shirley A Lauchie, Alanna Lohff, Charli Maldonado, Emily A Manley, Sari McLin, Caroline Mooney, Miatta Ndama, Omotara Ogundeyi, Nneoma Okeoma, Christopher Ordish, Nicholas Padilla, Christopher M Patrick, Tyler Paterson, Elliott E Phillips, Emily M Phillips, Neha Rampally, Caitlin Ribeiro, Madelaine K Robertson, Jon Thomson Rymer, Sean M Ryan, Megan Sammons, Anne K Scott, Ashley L Scott, Aya Shinomiya, Claire Smith, Kelsey Smith, Natalie L Smith, Margaret A Sobeski, Alia Suleiman, Jackie Swift, Satoko Takemura, Iris Talebi, Dorota Tarnogorska, Emily Tenshaw, Temour Tokhi, John J Walsh, Tansy Yang, Jane Anne Horne, Feng Li, Ruchi Parekh, Patricia K Rivlin, Vivek Jayaraman, Marta Costa, Gregory SXE Jefferis, Kei Ito, Stephan Saalfeld, Reed George, Ian A Meinertzhagen, Gerald M Rubin, Harald F Hess, Viren Jain, Stephen M Plaza   +107 more
doaj   +1 more source

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

Nature Neuroscience, 2022
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an eQTL
J. Bryois, D. Calini, W. Macnair, L. Foo, E. Urich, W. Ortmann, V. Iglesias, Suresh Selvaraj, E. Nutma, M. Marzin, S. Amor, Anna C. Williams, G. Castelo-Branco, V. Menon, P. D. De Jager, D. Malhotra   +15 more
semanticscholar   +1 more source

Mapping the mind of a fly

eLife, 2020
Scientists have created the most detailed map of the fruit fly brain to date, identifying over 25,000 neurons and 20 million synapses.
Jason Pipkin
doaj   +1 more source

DestVI identifies continuums of cell types in spatial transcriptomics data

Nature Biotechnology, 2022
Most spatial transcriptomics technologies are limited by their resolution, with spot sizes larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can alleviate this problem, current methods are limited to assessing ...
Romain Lopez, Baoguo Li, Hadas Keren-Shaul, Pierre Boyeau, M. Kedmi, D. Pilzer, Adam Jelinski, Ido Yofe, Eyal David, Allon Wagner, Can Ergen, Y. Addadi, O. Golani, F. Ronchese, Michael I. Jordan, I. Amit, N. Yosef   +16 more
semanticscholar   +1 more source

Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex

Frontiers in Neural Circuits, 2022
All brain functionality arises from the activity in neural circuits in different anatomical regions. These regions contain different circuits comprising unique cell types.
Stefan Blankvoort, Lene Christin Olsen, Lene Christin Olsen, Lene Christin Olsen, Clifford G. Kentros   +4 more
doaj   +1 more source

Tangential distribution of cell type and direction selectivity in monkey area MT [PDF]

Anais da Academia Brasileira de Ciências, 2020
Abstract: We studied the multiunit responses to moving and static stimuli from 585 cell clusters in area MT using multi-electrode arrays. Our aim was to explore if MT columns exhibit any larger-scale tangential organization or clustering based on their ...
ANTONIA CINIRA M. DIOGO, BRUSS LIMA, JULIANA G. M. SOARES, RICARDO GATTASS   +3 more
doaj   +1 more source