Results 31 to 40 of about 28,363,573 (344)

Molecular and spatial profiling of the paraventricular nucleus of the thalamus

eLife, 2023
The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked to cellular differences, the molecular identity and spatial ...
Claire Gao, Chiraag A Gohel, Yan Leng, Jun Ma, David Goldman, Ariel J Levine, Mario A Penzo   +6 more
doaj   +1 more source

Identification of Cell Subpopulations and Interactive Signaling Pathways From a Single-Cell RNA Sequencing Dataset in Osteosarcoma: A Comprehensive Bioinformatics Analysis

Frontiers in Oncology, 2022
Osteosarcoma is a type of highly aggressive bone tumor arising from primitive cells of mesenchymal origin in adults and is associated with a high rate of tumor relapse.
Rong Wu, Xiaojie Dou, Haidong Li, Zhenguo Sun, Heng Li, Yuxin Shen, Wei Weng, Jikang Min   +7 more
doaj   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

DNA methylation age of human tissues and cell types

Genome Biology, 2013
It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar   +1 more source

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine.

Neuron, 2022
Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are involved remain unclear.
Lite Yang, Mengyi Xu, Shamsuddin A. Bhuiyan, Jia Li, Jun Zhao, R. Cohrs, Justin T. Susterich, Sylvia Signorelli, U. Green, J. Stone, D. Levy, J. Lennerz, William Renthal   +12 more
semanticscholar   +1 more source

Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing data

Frontiers in Genetics, 2022
Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an effective treatment for ...
Ning Xu, Xiaojing Wang, Lili Wang, Yuan Song, Xianyou Zheng, Hai Hu, Hai Hu   +6 more
doaj   +1 more source

Neuronal cell types [PDF]

Current Biology, 2004
For the first time in any substantially complex CNS structure, the inventory of cell types in the retina appears to be virtually complete. Evidence for this comes partly from a new, unbiased, morphological sampling technique; from the sheer volume of well-visualized cells that is easily generated by modern cell-filling methods; from the three ...
openaire   +2 more sources

Benchmarking clustering algorithms on estimating the number of cell types from single-cell RNA-sequencing data

Genome Biology, 2022
A key task in single-cell RNA-seq (scRNA-seq) data analysis is to accurately detect the number of cell types in the sample, which can be critical for downstream analyses such as cell type identification.
Lijia Yu, Yue Cao, J. Yang, Pengyi Yang
semanticscholar   +1 more source

Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]

, 2019
Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Corbo, Joseph C, Hughes, Andrew E.O., Lawrence, Karen A, Murphy, Daniel P, Myers, Connie A   +4 more
core   +3 more sources

Insulin action in the brain: cell types, circuits, and diseases.

Trends in Neurosciences, 2022
Since its discovery over 100 years ago, insulin has been recognized as a key hormone in control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and many other disorders.
Wenqiang Chen, Weikang Cai, Benjamin Hoover, C. Kahn   +3 more
semanticscholar   +1 more source