Results 31 to 40 of about 5,097,355 (300)

Accumulation of Fat Not Responsible for Femoral Head Necrosis, Revealed by Single-Cell RNA Sequencing: A Preliminary Study

Biomolecules, 2023
The etiology of osteonecrosis of the femoral head (ONFH) is not yet fully understood. However, ONFH is a common disease with high morbidity, and approximately one-third of cases are caused by glucocorticoids.
Yingjie Wang, Dandan Li, Haijia Chen, Zhuolin Li, Bin Feng, Xisheng Weng   +5 more
doaj   +1 more source

STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS. [PDF]

, 2019
During epithelium tissue maintenance, lineages of cells differentiate and proliferate in a coordinated way to provide the desirable size and spatial organization of different types of cells.
Chen, Weitao, Nie, Qing, Qiu, Yuchi
core   +2 more sources

Navigating mouse cell types [PDF]

Nature Reviews Genetics, 2018
A new study reports the ‘Tabula Muris’, an atlas of single-cell RNA sequencing data from >100,000 cells across 20 mouse tissues.
openaire   +2 more sources

Context-dependent signaling of coincident auditory and visual events in primary visual cortex

eLife, 2019
Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound
Thomas Deneux, Evan R Harrell, Alexandre Kempf, Sebastian Ceballo, Anton Filipchuk, Brice Bathellier   +5 more
doaj   +1 more source

Cell type‐specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics

Molecular Oncology, 2020
Single‐cell transcriptomics have revolutionized our understanding of the cell composition of tumors and allowed us to identify new subtypes of cells. Despite rapid technological advancements, single‐cell analysis remains resource‐intense hampering the ...
Max Krämer, Patrick S. Plum, Oscar Velazquez Camacho, Kat Folz‐Donahue, Martin Thelen, Isabel Garcia‐Marquez, Christina Wölwer, Sören Büsker, Jana Wittig, Marek Franitza, Janine Altmüller, Heike Löser, Hans Schlößer, Reinhard Büttner, Wolfgang Schröder, Christiane J. Bruns, Hakan Alakus, Alexander Quaas, Seung‐Hun Chon, Axel M. Hillmer   +19 more
doaj   +1 more source

Phylogenetic Analysis of Cell Types using Histone Modifications

, 2013
In cell differentiation, a cell of a less specialized type becomes one of a more specialized type, even though all cells have the same genome. Transcription factors and epigenetic marks like histone modifications can play a significant role in the ...
Bucher, Philipp, Lin, Yu, Moret, Bernard M. E., Nair, Nishanth Ulhas   +3 more
core   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]

, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu, Dowdy, Steven F, Huggins, Ian J, Jadhav, Satish, Medina, Carlos A, Springer, Aaron D, van den Berg, Arjen   +6 more
core   +1 more source

Extensive cellular multi-tasking within Bacillus subtilis biofilms

mSystems, 2023
Bacillus subtilis is a soil-dwelling bacterium that can form biofilms, or communities of cells surrounded by a self-produced extracellular matrix. In biofilms, genetically identical cells often exhibit heterogeneous transcriptional phenotypes, so that ...
Sarah M. Yannarell, Eric S. Beaudoin, Hunter S. Talley, Alexi A. Schoenborn, Galya Orr, Christopher R. Anderton, William B. Chrisler, Elizabeth A. Shank   +7 more
doaj   +1 more source

Why isn’t each cell its own cell type? Diminishing returns of increasing cell type diversity can explain cell type allometry

Frontiers in Cell and Developmental Biology, 2022
Since the discovery of cells by Robert Hooke and Antoni van Leeuwenhoek in the 17th century, thousands of different cell types have been identified, most recently by sequencing-based single-cell profiling techniques. Yet, for many organisms we still do not know, how many different cell types they are precisely composed of.
openaire   +3 more sources

Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

eLife
The central complex (CX) plays a key role in many higher-order functions of the insect brain including navigation and activity regulation. Genetic tools for manipulating individual cell types, and knowledge of what neurotransmitters and neuromodulators ...
Tanya Wolff, Mark Eddison, Nan Chen, Aljoscha Nern, Preeti Sundaramurthi, Divya Sitaraman, Gerald M Rubin   +6 more
doaj   +1 more source