Results 101 to 110 of about 15,438,001 (312)

Osmolarity‐Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology

Advanced Science
Osteoarthritis (OA) is a multifactorial degenerative joint disease of which the underlying mechanisms are yet to be fully understood. At the molecular level, multiple factors including altered signaling pathways, epigenetics, metabolic imbalance ...
Kannan Govindaraj, Marieke Meteling, Jeroen vanRooij, Malin Becker, Andre J. vanWijnen, Jeroen J. J. P. vanden Beucken, Yolande F. M. Ramos, Joyce vanMeurs, Janine N. Post, Jeroen Leijten   +9 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Dependence of Induced Transmembrane Potential on Cell Density, Arrangement, and Cell Position

, 2008
—A nonuniform transmembrane potential (TMP) is induced on a cell membrane exposed to external electric field. If the induced TMP is above the threshold value, cell membrane becomes permeabilized in a reversible process called electropermeabilization ...
Inside A Cell System
core  

Deconstructing olfactory stem cell trajectories at single-cell resolution [PDF]

, 2017
A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis. Adult stem cells maintain and regenerate multiple mature cell lineages
Ngai, John, Nir Yosef, Yoon Gi Choi, Gadye, Levi, Purdom, Elizabeth, Wagner, Allon, Choi, Yoon Gi, Risso, Davide, Michael B. Cole, Levi Gadye, Ariane Baudhuin, Quetzal Flores, Fletcher, Russell B, Davide Risso, Street, Kelly N, John Ngai, Kelly N. Street, Diya Das, Yosef, Nir, Dudoit, Sandrine, Flores, Quetzal, Baudhuin, Ariane, Sandrine Dudoit, Das, Diya, Elizabeth Purdom, Cole, Michael B, Russell B. Fletcher, Allon Wagner   +27 more
core   +1 more source

Comparison of Real-Time Methods Demonstrating the Effects of Reduced Glutathione on Olfactory Neuroblasts

Applied Sciences
The objective of the present study was to compare recent methods for characterizing cell modifications. We studied the effect of extracellular reduced glutathione (GSH) on an olfactory neuroblast cell line (13s24).
Alain Géloën, Emmanuelle Berger
doaj   +1 more source

Rounding up plant cells

International Journal of Plant Biology, 2010
Compared to animal cells, plant cells are typically non-spherical, which may bias morphometric and fluorimetric analyses, including flow cytometry and other approaches used in the study of cellular biodiversity.
Sergio Ochatt, Anne Moessner
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Identità Differenze Conflitti

, 2007
Volume collettaneo che raccoglie gli interventi e i contributi del Convegno "Identità Differenze Conflitti" tenutosi a Venezia nel settembre 2007 a conclusione del PRIN 2004 (resp. naz. e loc. prof. L. Ruggiu)
Mora, Francesco, MORA F., Ruggiu, Luigi, VOLUME COLLETTANEO, RUGGIU L.   +4 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Cell tension and mechanical regulation of cell volume

Molecular Biology of the Cell, 2018
Animal cells use an unknown mechanism to control their growth and physical size. Here, using the fluorescence exclusion method, we measure cell volume for adherent cells on substrates of varying stiffness. We discover that the cell volume has a complex dependence on substrate stiffness and is positively correlated with the size of the cell adhesion to ...
Nicolas, Perez Gonzalez, Jiaxiang, Tao, Nash D, Rochman, Dhruv, Vig, Evelyn, Chiu, Denis, Wirtz, Sean X, Sun   +6 more
openaire   +2 more sources