Results 91 to 100 of about 15,438,001 (312)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Cell volume regulatory ion channels in cell proliferation and cell death.

, 2007
Alterations of cell volume are key events during both cell proliferation and apoptotic cell death. Cell proliferation eventually requires an increase of cell volume, and apoptosis is typically paralleled by cell shrinkage.
HUBER SM, Stephan M. Huber, Philipp Lang, Karl Lang, RITTER M, Michael Föller, Ildiko Szabo, LANG K, GULBINS E., LANG, F, Florian Lang, LANG P, SZABO', ILDIKO', FÖLLER M, Markus Ritter, VERENINOV A, Alexey Vereninov, Erich Gulbins   +17 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

ISLET VOLUME AND INDEXES OF β-CELL FUNCTION IN HUMANS

, 2016
Islet volume and endocrine pancreas architecture (islet size distribution) may be independent determinants of beta cell function. Furthermore, the accuracy of HOMA indexes in predicting β-cell mass has never been assessed.
Mercalli, Alessia, Balzano, Gianpaolo, Piemonti, Lorenzo, Scavini, Marina, Melzi, Raffaella, BONADONNA, Riccardo, Nano, Rita, Rita Nano   +7 more
core   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Burton, Paul, Lomax, G, Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM, Baltz, Jay M., Andrews, Peter W., Ng, Huck Hui, Stacey, Glyn N., Bredenoord, Annelien L., Knoppers, Bartha Maria, Hull, Sara Chandros   +44 more
core   +1 more source

Neutrophils actively swell to potentiate rapid migration

eLife
While the involvement of actin polymerization in cell migration is well-established, much less is known about the role of transmembrane water flow in cell motility.
Tamas L Nagy, Evelyn Strickland, Orion D Weiner   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

YAP and TAZ regulate cell volume [PDF]

, 2019
How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner.
Fu, Vivian, Denis Wirtz, Takaesu, Felipe, Toler, Ben, Sablich, Lucia, Huang, Jessie, Kai Yao, Felipe Takaesu, Chengappa, Pragati, Kun-Liang Guan, Lambrus, Bram, Jessie Huang, Sun, Sean X, Nicolas A. Perez-Gonzalez, Wirtz, Denis, Vivian Fu, Eliana Crentsil, Petrie, Ryan J, Lucia Sablich, Ryan J. Petrie, Flanary, Shannon, Pragati Chengappa, Tia M. Jones, Andrew J. Holland, Steven An, Jones, Tia M, Guan, Kun-Liang, Nash D. Rochman, Sean X. Sun, Jiaxiang Tao, Rochman, Nash D, Tao, Jiaxiang, An, Steven, Holland, Andrew J, Crentsil, Eliana, Perez-Gonzalez, Nicolas A, Le, Minh-Tam Tran, Shannon Flanary, Bram Lambrus, Yao, Kai, Minh-Tam Tran Le, Ben Toler   +41 more
core   +1 more source

A single-cell 3D dynamic volume control system for chondrocytes

BioTechniques
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang, Yiyao Wang, Yanjun Zhang, Xiaochun Wei, Weiyi Chen, Quanyou Zhang   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source