Results 91 to 100 of about 14,829,970 (312)

Generation and regulation of microtubule network asymmetry to drive cell polarity [PDF]

, 2020
Microtubules control cell architecture by serving as a scaffold for intracellular transport, signaling, and organelle positioning. Microtubules are intrinsically polarized, and their orientation, density, and post-translational modifications both respond
Meiring, Joyce C.M., Sub Cell Biology, Celbiologie, Shneyer, Boris I., Akhmanova, Anna   +4 more
core   +1 more source

Neutrophils actively swell to potentiate rapid migration

eLife
While the involvement of actin polymerization in cell migration is well-established, much less is known about the role of transmembrane water flow in cell motility.
Tamas L Nagy, Evelyn Strickland, Orion D Weiner   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation [PDF]

, 2013
Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear.
ALLENA, Rachele, Sharpe, J., AUBRY, Denis, SHARPE, James   +3 more
core   +1 more source

A single-cell 3D dynamic volume control system for chondrocytes

BioTechniques
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang, Yiyao Wang, Yanjun Zhang, Xiaochun Wei, Weiyi Chen, Quanyou Zhang   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Osmolarity‐Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology

Advanced Science
Osteoarthritis (OA) is a multifactorial degenerative joint disease of which the underlying mechanisms are yet to be fully understood. At the molecular level, multiple factors including altered signaling pathways, epigenetics, metabolic imbalance ...
Kannan Govindaraj, Marieke Meteling, Jeroen vanRooij, Malin Becker, Andre J. vanWijnen, Jeroen J. J. P. vanden Beucken, Yolande F. M. Ramos, Joyce vanMeurs, Janine N. Post, Jeroen Leijten   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Identità Differenze Conflitti

, 2007
Volume collettaneo che raccoglie gli interventi e i contributi del Convegno "Identità Differenze Conflitti" tenutosi a Venezia nel settembre 2007 a conclusione del PRIN 2004 (resp. naz. e loc. prof. L. Ruggiu)
Mora, Francesco, MORA F., Ruggiu, Luigi, VOLUME COLLETTANEO, RUGGIU L.   +4 more
core  

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source