Results 81 to 90 of about 14,829,970 (312)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Andrews, Peter W., Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Baltz, Jay M., Knoppers, Bartha Maria, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Ng, Huck Hui, Stacey, Glyn N., Burton, Paul, Lomax, G, Bredenoord, Annelien L., Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Hull, Sara Chandros, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM   +44 more
core   +1 more source

Species-specific and environment-sensitive functional traits in six steppe plant species with different roles in community

Historia Naturalis Bulgarica
Plant functional traits are often considered as indicators of plant-environment relationship; however, some plant features can be highly taxonomic-specific.
Shinekhuu Tumurjav, Larissa Ivanova, Yurii Rupyshev, Svetlana Migalina, Sergey Bazha, Leonid Ivanov   +5 more
doaj   +1 more source

Size and carbon content of sub-seafloor microbial cells at Landsort Deep, Baltic Sea

Frontiers in Microbiology, 2016
The discovery of a microbial ecosystem in ocean sediments has evoked interest in life under extreme energy limitation and its role in global element cycling.
Stefan Braun, Yuki Morono, Sten Littmann, Marcel Kuypers, Hüsnü Aslan, Mingdong Dong, Bo Barker Jørgensen, Bente Aagaard Lomstein, Bente Aagaard Lomstein   +8 more
doaj   +1 more source

Cell Volume Changes and Membrane Ruptures Induced by Hypotonic Electrolyte and Sugar Solutions

Frontiers in Physiology, 2020
The cell volume changes induced by hypotonic electrolyte and sucrose solutions were studied in Chinese-hamster-ovary epithelial cells. The effects in the solutions with osmolarities between 32 and 315 mosM/L and distilled water were analyzed using bright-
Bojan Božič, Špela Zemljič Jokhadar, Špela Zemljič Jokhadar, Luka Kristanc, Gregor Gomišček, Gregor Gomišček   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly

, 2019
The apical Par complex, which contains atypical protein kinase C (aPKC), Bazooka (Par-3), and Par-6, is required for establishing polarity during asymmetric division of neuroblasts in Drosophila, and its activity depends on L(2)gl.

core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
core   +1 more source