Results 131 to 140 of about 15,438,001 (312)

Cell volume change through water efflux impacts cell stiffness and stem cell fate

, 2017
Cells alter their mechanical properties in response to their local microenvironment; this plays a role in determining cell function and can even influence stem cell fate. Here, we identify a robust and unified relationship between cell stiffness and cell
Burnette, Dylan T., Jeffrey R. Moore, Enhua H. Zhou, Mooney, David J., Frederick C. Mackintosh, Moore, Jeffrey R., Mackintosh, Frederick C., Jensen, Mikkel H., Pegoraro, Adrian F., Kasza, Karen E., David J. Mooney, Weitz, David A., Adrian F. Pegoraro, Yulong Han, Zhou, Enhua H., Karen E. Kasza, David A. Weitz, Lippincott-Schwartz, Jennifer, Praveen R. Arany, Han, Yulong, Ming Guo, Mao, Angelo, Arany, Praveen R., Fredberg, Jeffrey J., Jennifer Lippincott-Schwartz, Angelo Mao, Jeffrey J. Fredberg, Dylan T. Burnette, Mikkel H. Jensen, Guo, Ming   +29 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

RNAi of CNS-expressed gene DjSlk induces morphogenetic malformation and death in planarian Dugesia japonica

Invertebrate Survival Journal, 2016
Ste20-like kinases are critically multifuctional proteins which play important roles in varieties of celluar processes and physiological events. Here, We characterized a Ste20-like kinase gene (DjSlk) in planarian Dugesia japonica.
X Chen, H Zhen, S Wu, Q Lu, Q Pang, B Zhao   +5 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Packed cell wall volume (PCV) of each cell line during cell wall preparation.

, 2014
Packed cell wall volume (PCV) of each cell line during cell wall preparation.
Utku Avci (282268), Jin Qian (35219), Michael G. Hahn (282272), Yunqiao Pu (678767), Arthur J. Ragauskas (678769), Marcia J. Kieliszewski (678770), Allison Arter (678768), Sivakumar Pattathil (282269), Liwei Chen (143453), Li Tan (157486)   +9 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Postoperative autologous peripheral blood mononuclear cell therapy in the rehabilitation of children with chronic hypertrophic rhinitis: a prospective comparative study

Chronic hypertrophic rhinitis in children is a common pathology associated with inferior turbinate hypertrophy, persistent nasal obstruction, and impaired quality of life.
Maniuc, Mihail, Ababii, Polina, Furculița, Daniel, Danilov, Lucian   +3 more
core   +1 more source