Results 141 to 150 of about 15,438,001 (312)

Exendin-4 Increases the Expression of Hypoxia-Inducible Factor-1α in Rat Islets and Preserves the Endocrine Cell Volume of Both Free and Macroencapsulated Islet Grafts

, 2012
In this study, we evaluated the effects of exendin-4 on free and encapsulated islet grafts in a rodent model. We also investigated the role of a transcription factor, hypoxia-inducible factor-1 (HIF-1), in mediating the beneficial effects of exendin-4 ...
Sorenby, AK, Sörenby, Anne K., Sharma, Amit, Sharma, A, Tibell, AB, Kumagai-Braesch, M,, Wang, F, Wang, Feng, Jia, X,, Yamamoto, S,, Tibell, Annika B., Wernerson, Annika, Kumagai-Braesch, Makiko, Yamamoto, Shinji,, Jia, Xiaohui, Wernerson, AM   +15 more
core   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science
Tumor development and progression involve biophysical changes across spatial scales, from the subcellular to the multicellular tissue scale. While cells are known to dynamically regulate their volumes and mechanics in dependence of cell state and ...
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3

, 2008
SummaryLimited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem cells and contributes to the relative quiescence and durability of the stem cell population in vivo.
Riese, Matthew J, Woo, Minna, Karlsson, Göran, Milne, Craig D, Lo Celso, Cristina, Karlsson, Göran,, Scadden, David T, Fleming, Heather E, Paige, Christopher J, Karlsson, Stefan, Janzen, Viktor, Reynolds, Griffin, Karlsson, Stefan,, Riedt, Tamara, Lund University.   +14 more
core   +1 more source

Red cell volume in diabetes [PDF]

Diabetologia, 1982
W. Beautyman, E. Ernst
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

An improved cell-volume analyzer [PDF]

, 1970
Design and operation of cell-volume analyzer friction, glaze ice, and studded tire effects on ...
Herzenberg, L. A., Merrill, J. T., Veizades, N., Hulett, H. R., Wolf, P. L.   +4 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Relative levels, determined from 2D-NMR volume-integrals, of various units in the whole-cell-walls of sweet sorghum Della and the energy sorghum TX08001.

, 2018
Relative levels, determined from 2D-NMR volume-integrals, of various units in the whole-cell-walls of sweet sorghum Della and the energy sorghum TX08001.
Steven D. Karlen (1904866), Fachuang Lu (2261938), Sara N. Olson (483642), John E. Mullet (615606), Kimberley B. Ritter (5131040), William L. Rooney (615605), Brian A. McKinley (5131037), Dustin W. Herb (5131043), John Ralph (781218)   +8 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source