Results 161 to 170 of about 2,031,505 (263)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Alexander Leaf, MD (1920 -2012) – A Tribute to a Life in Physiology and Medicine

Frontiers in Physiology, 2013
George E Billman
doaj   +1 more source

Estimation of minimum centrifugation time of microhematocrit tubes to obtain accurate results of packed cell volume and total solids in donkeys, dogs, sheep, and cows. [PDF]

J Vet Diagn Invest
Oliva D, Lardé H, Bouillon J, Whiston R, Peda A, Dowling P, Chapuis RJJ.   +6 more
europepmc   +1 more source

Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation. [PDF]

Front Cell Dev Biol, 2021
Li Y, Zhou X, Sun SX.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction. [PDF]

Elife
Bu X, Ashby N, Vitali T, Lee S, Gottumukkala A, Yun K, Tabbara S, Latham P, Teal C, Chung I.   +9 more
europepmc   +1 more source

Membrane Localization of Piezo1 in the Context of Its Role in the Regulation of Red Blood Cell Volume. [PDF]

Front Physiol, 2022
Božič B, Svetina S.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Prediction of the space group and cell volume by training a convolutional neural network with primitive 'ideal' diffraction profiles and its application to 'real' experimental data. [PDF]

J Appl Crystallogr
Ozaki H, Ishida N, Kiyobayashi T.
europepmc   +1 more source

Cell volume restriction by mercury chloride reduces M1-like inflammatory response of bone marrow-derived macrophages. [PDF]

Front Pharmacol, 2022
Chuang YC, Wu SY, Huang YC, Peng CK, Tang SE, Huang KL.   +5 more
europepmc   +1 more source