A novel connection between the Cell Wall Integrity and the PKA pathways regulates cell wall stress response in yeast [PDF]
Scientific Reports, 2017 Fungal cells trigger adaptive mechanisms to survive in situations that compromise cell wall integrity. We show here that the global transcriptional response elicited by inhibition of the synthesis of β-1,3-glucan by caspofungin, encompasses a set of ...
Raúl García +5 more
doaj +4 more sources
The Aspergillus fumigatus cell wall integrity signalling pathway: drug target, compensatory pathways and virulence [PDF]
Frontiers in Microbiology, 2015 Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients. The fungal cell wall prevents the cell from lysing and protects the fungus against environmental stress ...
Vito eValiante +3 more
doaj +3 more sources
The Cell Wall Integrity Signaling Pathway and Its Involvement in Secondary Metabolite Production [PDF]
Journal of Fungi, 2017 The fungal cell wall is the external and first layer that fungi use to interact with the environment. Every stress signal, before being translated into an appropriate stress response, needs to overtake this layer.
Vito Valiante
doaj +3 more sources
Clotrimazole-Induced Oxidative Stress Triggers Novel Yeast Pkc1-Independent Cell Wall Integrity MAPK Pathway Circuitry [PDF]
Journal of Fungi, 2021 Azoles are one of the most widely used drugs to treat fungal infections. To further understand the fungal response to azoles, we analyzed the MAPK circuitry of the model yeast Saccharomyces cerevisiae that operates under treatment with these antifungals.
Ángela Sellers-Moya +3 more
doaj +6 more sources
The Cell Wall Integrity Pathway Contributes to the Early Stages of Aspergillus fumigatus Asexual Development. [PDF]
Appl Environ Microbiol, 2020 A remarkable feature of the human pathogen Aspergillus fumigatus is its ability to produce impressive amounts of infectious propagules known as conidia. These particles reach immunocompromised patients and may initiate a life-threatening mycosis.
Rocha MC +8 more
europepmc +6 more sources
Cell fusion in yeast is negatively regulated by components of the cell wall integrity pathway. [PDF]
Mol Biol Cell, 2019 During mating, Saccharomyces cerevisiae cells must degrade the intervening cell wall to allow fusion of the partners. Because improper timing or location of cell wall degradation would cause lysis, the initiation of cell fusion must be highly regulated.
Hall AE, Rose MD.
europepmc +3 more sources
Signalling through the yeast MAPK Cell Wall Integrity pathway controls P-body assembly upon cell wall stress. [PDF]
Sci Rep, 2019 AbstractPost-transcriptional control of mRNA is a key event in the regulation of gene expression. From yeast to human cells, P-bodies are cytoplasmic RNA-protein aggregates that play an essential role in this process, particularly under stress conditions.
García R +6 more
europepmc +7 more sources
Homeostasis of cell wall integrity pathway phosphorylation is required for the growth and pathogenicity of Magnaporthe oryzae. [PDF]
Mol Plant Pathol, 2022 Abstract The cell wall provides a crucial barrier to stress imposed by the external environment. In the rice blast fungus Magnaporthe oryzae , this stress response is mediated by the cell wall integrity (CWI) pathway, consisting of a well‐characterized protein ...
Cai Y +7 more
europepmc +3 more sources
Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway. [PDF]
Genetics, 2015 AbstractMany microbial communities contain organized patterns of cell types, yet relatively little is known about the mechanism or function of this organization. In colonies of the budding yeast Saccharomyces cerevisiae, sporulation occurs in a highly organized pattern, with a top layer of sporulating cells sharply separated from an underlying layer of
Piccirillo S +5 more
europepmc +4 more sources
Author Correction: Signalling through the yeast MAPK Cell Wall Integrity pathway controls P-body assembly upon cell wall stress. [PDF]
Sci Rep, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
García R +6 more
europepmc +4 more sources