iScience, 2022 Summary: Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular mechanisms through which cholesterol binding alters channel function are virtually ...
Nicolas Barbera +8 more
doaj +1 more source
ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations. [PDF]
, 2008 The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 μg/ml, 0.1 μg/ml or 1.0 μg/ml) were measured using the alkaline single-cell gel electrophoresis ...
Ahmad, Muhammad S. +6 more
core +3 more sources
Cell Reports, 2016 Release site clearance is an important process during synaptic vesicle (SV) recycling. However, little is known about its molecular mechanism. Here we identify self-assembly of exocytosed Synaptobrevin 2 (Syb2) and Synaptophysin 1 (Syp1) by homo- and ...
Rajit Rajappa +4 more
doaj +1 more source
In vitro assembly, positioning and contraction of a division ring in minimal cells
Nature Communications, 2022 Constructing a minimal protein machinery for self-division of membrane compartments is a major goal of bottom-up synthetic biology. Here, authors achieved the assembly, placement and onset of contraction of a minimal division ring in lipid vesicles.
Shunshi Kohyama +2 more
doaj +1 more source
Temperature-sensitive migration dynamics in neutrophil-differentiated HL-60 cells
Scientific Reports, 2022 Cell migration plays an essential role in wound healing and inflammatory processes inside the human body. Peripheral blood neutrophils, a type of polymorphonuclear leukocyte (PMN), are the first cells to be activated during inflammation and subsequently ...
Galina Khachaturyan +9 more
doaj +1 more source
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Acta Neuropathologica Communications, 2021 The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction.
Qi Yuan +9 more
doaj +1 more source
Application of Biophysical Techniques to Cellular and Molecular Oncology [PDF]
Cancers, 2023 Dysregulated cellular processes drive malignant transformation, tumor progression, and metastasis, and affect responses to therapies [...]
Lidke, D.S., Gillette, J.M., Cambi, A.
openaire +2 more sources
A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. [PDF]
, 2014 Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this study,
Agard, David A +5 more
core +2 more sources
Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors
BME Frontiers, 2022 Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation, is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living cells.
J. Tu, A. Yu
semanticscholar +1 more source