Results 201 to 210 of about 488,024 (316)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cellular networks of oscillators

, 1992
The problem of using dynamical equilibria of a Cellular Neural Network (CNN) of relaxation oscillators is faced. The behavior of a planar matrix and of a two-torus of connected oscillators is investigated by computer simulation.
BALSI, Marco, CIMAGALLI, Valerio, A. Barone   +2 more
core  

Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence. [PDF]

JHEP Rep
Seshachalam VP, Sari IN, Toh K, Majee P, Chong SL, Sekar K, Aiderus A, Idzham K, Qi OY, Chong LY, Caldez M, Shanmugam R, Ying DHH, Lee E, Toh J, Lele W, Lee JYJ, Zhong G, Chew SC, Chen GB, Wu L, Chung AYF, Cheow PC, Kam JH, Kow AWC, Leow WQ, Jegannathan N, Chen K, Bunchaliew C, de Villa VH, Koh PS, Bonney G, Goh BKP, Tam WL, Loo LH, Yeong J, Tergaonkar V, Chow PKH.   +37 more
europepmc   +1 more source

A Review on Rainfall Measurement Based on Commercial Microwave Links in Wireless Cellular Networks. [PDF]

Sensors (Basel), 2022
Lian B, Wei Z, Sun X, Li Z, Zhao J.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Towards a business model for cellular network and telecommunication operators: a theoretical framework

, 2008
Cellular networks and telecommunications bring major change to the way businesses are conducted. Mobility has become one of the main priorities for users and this has impacted on cellular networks and telecommunication operators (CNTOs).
El-Haddadeh, R, Avison, D, Al-Debei, MM
core  

High-temperature strength in an additively manufactured Al-based superalloy with stable nanoscale eutectic cellular networks. [PDF]

Nat Commun
Ma S, Chen Z, Fang H, Ji G, Wang M, Cui Y, Li Y, Zhong S, Chen H, Wu Y, Zhou Y, Nie S, Lu J.   +12 more
europepmc   +1 more source

Elastic network modeling of cellular networks unveils sensor and effector genes that control information flow. [PDF]

PLoS Comput Biol, 2022
Acar O, Zhang S, Bahar I, Carvunis AR.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reciprocal folding dynamics in cellular networks at the stroma-basement membrane interface. [PDF]

Acta Biomater
Jo Y, Yim D, Park CE, Yong I, Lee J, Ahn KH, Yang C, Chang JB, Kim TS, Shin JH, Kim T, Kim P.   +11 more
europepmc   +1 more source