Results 201 to 210 of about 224,348 (348)

Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions. [PDF]

BMC Biol, 2023
Wang M, He B, Hao Y, Srinivasan D, Shrinet J, Fraser P.   +5 more
europepmc   +1 more source

Cellular reprogramming dynamics follow a simple one-dimensional reaction\n coordinate [PDF]

, 2015
Sai Teja Pusuluri, Alex Lang, Pankaj Mehta, Horacio E. Castillo   +3 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Exosomal regulation of cellular reprogramming and polarization in the tumor microenvironment. [PDF]

Cancer Cell Int
Bayat M, Shahabi P, Rezaei T, Nahand JS.
europepmc   +1 more source

Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality? [PDF]

Chronic Dis Transl Med, 2023
Du J, Liu X, Wong CWY, Wong KKY, Yuan Z.
europepmc   +1 more source

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling [PDF]

, 2017
Chantel Samardzija, David W. Greening, Ruth M. Escalona, Maoshan Chen, Maree Bilandzic, Rodney B. Luwor, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed   +8 more
openalex   +1 more source

Vitamin B12 boosts cellular reprogramming

Nature Aging, 2023
openaire   +2 more sources

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Redefining cellular reprogramming with advanced genomic technologies. [PDF]

Nat Rev Genet
Morris SA.
europepmc   +1 more source