Results 201 to 210 of about 229,443 (256)

Factors governing cellular reprogramming competence in Arabidopsis adventitious root formation. [PDF]

Dev Cell
Damodaran S, Strader LC.
europepmc   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

Orchestrating an immune response to cancer with cellular reprogramming. [PDF]

Genes Immun
Zimmermannova O, Ferreira AG, Pereira CF.   +2 more
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Correction: Therapeutic potential of NGF-enriched extracellular vesicles in modulating neuroinflammation and enhancing peripheral nerve remyelination

Acta Neuropathologica Communications
Hancheol Yeo, Yoo Jung Kim, Jaekwon Seok, Yeonjoo Kwak, Soo Bin Jang, Na Hee Lim, Kwonwoo Song, Junghoon Lee, Min Chul Cho, Soo Woong Kim, Ssang-Goo Cho   +10 more
doaj   +1 more source

Cellular reprogramming as a tool to model human aging in a dish. [PDF]

Nat Commun
Pitrez PR, Monteiro LM, Borgogno O, Nissan X, Mertens J, Ferreira L.   +5 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment. [PDF]

Curr Cardiol Rep
Yao B, Lei Z, Gonçalves MAFV, Sluijter JPG.   +3 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity. [PDF]

Nat Commun
Katsuda T, Sussman JH, Ito K, Katznelson A, Yuan S, Takenaka N, Li J, Merrell AJ, Cure H, Li Q, Rasool RU, Asangani IA, Zaret KS, Stanger BZ.   +13 more
europepmc   +1 more source